Relaxation of rabbit cavernous smooth muscle to 17 beta estradiol: a non-genomic, NO-independent mechanism
DC Field | Value | Language |
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dc.contributor.author | Kim, Sae-Chul | - |
dc.contributor.author | Seo, Kyung-Kun | - |
dc.contributor.author | Myung, Soon-Chul | - |
dc.contributor.author | Lee, Moo Yeol | - |
dc.date.available | 2019-05-30T08:37:26Z | - |
dc.date.issued | 2004-06 | - |
dc.identifier.issn | 1008-682X | - |
dc.identifier.issn | 1745-7262 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24841 | - |
dc.description.abstract | Aim: To investigate whether estrogen was involved in relaxation of rabbit cavernous smooth muscle. Methods: Relaxation response of the rabbit cavernous smooth muscles to 17beta-estradiol (0.3, 3, 30 and 300 nmol/L) were observed in vitro. The response of the muscle strips to estrogen after incubation with either actinomycin D (10 mumol/L) or L-NAME (10 mumol/L) were also evaluated. Inside-out mode of patch clamp in a single smooth muscle cell was applied to investigate the Maxi-K channel activities. Results: Estrogen caused a dose-dependent relaxation of the strips precontracted with norepinephrine. The maximal response was noted about 10 minutes after treatment. The estrogen-induced relaxation was prevented by neither actinomycin D nor L-NAME, suggesting that the response was not mediated by gene transcription or nitric oxide (NO). Application of 17beta-estradiol increased the Maxi-K channel activities. Conclusion: 17beta-estradiol may be involved in relaxation of rabbit cavernous smooth muscles via a non-genomic and NO independent mechanism. 17beta-estradiol stimulates Maxi-K channel of the rabbit cavernous myocyte. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SCIENCE CHINA PRESS | - |
dc.title | Relaxation of rabbit cavernous smooth muscle to 17 beta estradiol: a non-genomic, NO-independent mechanism | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | ASIAN JOURNAL OF ANDROLOGY, v.6, no.2, pp 127 - 131 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000221917800010 | - |
dc.identifier.scopusid | 2-s2.0-2942687038 | - |
dc.citation.endPage | 131 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 127 | - |
dc.citation.title | ASIAN JOURNAL OF ANDROLOGY | - |
dc.citation.volume | 6 | - |
dc.identifier.url | http://www.asiaandro.com/archive/1008-682X/6/127.htm | - |
dc.type.docType | Article | - |
dc.publisher.location | 중국 | - |
dc.subject.keywordAuthor | 17 beta-estradiol | - |
dc.subject.keywordAuthor | cavernous smooth muscles | - |
dc.subject.keywordAuthor | Maxi-K channel | - |
dc.subject.keywordAuthor | relaxation | - |
dc.subject.keywordPlus | DEPENDENT MECHANISMS | - |
dc.subject.keywordPlus | CORONARY-ARTERIES | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | K+ CHANNELS | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | 17-BETA-ESTRADIOL | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | CGMP | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Andrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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