Inhibition of nitric oxide generation by 23,24-dihydrocucurbitacin D in mouse peritoneal macrophages
DC Field | Value | Language |
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dc.contributor.author | Park, Chang Seok | - |
dc.contributor.author | Lim, Hyun | - |
dc.contributor.author | Han, Kee Jung | - |
dc.contributor.author | Baek, Sun Heum | - |
dc.contributor.author | Sohn, Hyung Ok | - |
dc.contributor.author | Lee, Dong Wook | - |
dc.contributor.author | Kim, Yang-Gyun | - |
dc.contributor.author | Yun, Hye-Young | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Kwon, Nyoun Soo | - |
dc.date.available | 2019-05-30T08:37:36Z | - |
dc.date.issued | 2004-05 | - |
dc.identifier.issn | 0022-3565 | - |
dc.identifier.issn | 1521-0103 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24846 | - |
dc.description.abstract | Nitric oxide (NO) has various physiological functions. However, uncontrolled overproduction of NO can be toxic in many pathologic conditions involving inflammatory tissue damage. In the present study, we examined effects of 23,24-dihydrocucurbitacin D (DHCD) isolated from the root of Bryonia alba L. on macrophage NO generation. DHCD (< 80 &mu;M) effectively abolished NO generation from macrophages activated with lipopolysaccharide and interferon-&gamma;. DHCD decreased the levels of protein and mRNA for inducible NO synthase ( iNOS). DHCD potently blocked nuclear factor-&kappa;B (NF-&kappa;B) activation, a process necessary for transcriptional activation of iNOS. These results suggested that DHCD inhibited NO generation by blocking NF-&kappa;B activation and iNOS gene transcription. Because NF-&kappa;B activation is necessary not only for NO generation but also for many inflammatory processes, DHCD and its derivatives could be developed as anti-inflammatory drugs. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | - |
dc.title | Inhibition of nitric oxide generation by 23,24-dihydrocucurbitacin D in mouse peritoneal macrophages | - |
dc.type | Article | - |
dc.identifier.doi | 10.1124/jpet.103.063693 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, v.309, no.2, pp 705 - 710 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000220972900035 | - |
dc.identifier.scopusid | 2-s2.0-11144353961 | - |
dc.citation.endPage | 710 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 705 | - |
dc.citation.title | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.citation.volume | 309 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | BARR-VIRUS ACTIVATION | - |
dc.subject.keywordPlus | BRYONIA-ALBA L | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | BACTERIAL LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | CUCURBITANE TRITERPENOIDS | - |
dc.subject.keywordPlus | 2-STAGE CARCINOGENESIS | - |
dc.subject.keywordPlus | ANTITUMOR SUBSTANCES | - |
dc.subject.keywordPlus | MURINE MACROPHAGES | - |
dc.subject.keywordPlus | SYNTHASE GENE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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