Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors
DC Field | Value | Language |
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dc.contributor.author | Xu, Yu-Wen | - |
dc.contributor.author | Zhao, Gui-Sen | - |
dc.contributor.author | Shin, Cha-Gyun | - |
dc.contributor.author | Zang, Heng-Chang | - |
dc.contributor.author | Lee, Chong-Kyo | - |
dc.contributor.author | Lee, Yong Sup | - |
dc.date.available | 2019-05-30T09:32:11Z | - |
dc.date.issued | 2003-08 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24948 | - |
dc.description.abstract | HIV-1 integrase (IN) is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. In the present study, we have designed, synthesized and tested a series of caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors. Among these compounds, we found that HIV integrase inhibitory activities of compounds III-3 and III-4 were more potent than L-chicoric acid (IC50 = 11.8 mug/mL) and others were comparable to L-chicoric acid. Furthermore, the structure-activity relationships of these compounds were studied. The information gathered from this paper will be useful in the development and design of HIV-1 integrase inhibitors in the future. (C) 2003 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0968-0896(03)00372-9 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.11, no.17, pp 3589 - 3593 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000184865100004 | - |
dc.identifier.scopusid | 2-s2.0-0043125683 | - |
dc.citation.endPage | 3593 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 3589 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | VIRUS TYPE-1 INTEGRASE | - |
dc.subject.keywordPlus | DICAFFEOYLTARTARIC ACIDS | - |
dc.subject.keywordPlus | POTENT INHIBITORS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | INVITRO | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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