Bax-dependent apoptosis induced by ceramide in HL-60 cells
DC Field | Value | Language |
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dc.contributor.author | Kim, HJ | - |
dc.contributor.author | Mun, JY | - |
dc.contributor.author | Chun, YJ | - |
dc.contributor.author | Choi, KH | - |
dc.contributor.author | Kim, MY | - |
dc.date.available | 2019-05-30T09:38:40Z | - |
dc.date.issued | 2001-09 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.issn | 1873-3468 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25183 | - |
dc.description.abstract | Ceramide is an important lipid messenger involved in mediating a variety of cell functions including apoptosis. In this study, we show that antisense bax inhibits cytochrome c release, poly(ADP-ribose)polymerase cleavage and cell death induced by ceramide in HL-60 cells. In addition, ceramide induces translocation of Bax to mitochondria. The addition of the broad spectrum caspase inhibitor zVAD-fmk prevented ceramide-induced apoptotic cell death but did not inhibit translocation of Bax and mitochondrial cytochrome c release. Furthermore, ceramide inhibits the expression of the antiapoptotic protein Bcl-xL with an increase in the ratio of Bax to Bcl-xL. These data provide direct evidence that Bax plays an important role in regulating ceramide-induced apoptosis. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Bax-dependent apoptosis induced by ceramide in HL-60 cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0014-5793(01)02836-8 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.505, no.2, pp 264 - 268 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000171125800013 | - |
dc.identifier.scopusid | 2-s2.0-0035860393 | - |
dc.citation.endPage | 268 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 264 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 505 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | ceramide | - |
dc.subject.keywordAuthor | Bax | - |
dc.subject.keywordAuthor | Bcl-xL | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | caspase | - |
dc.subject.keywordPlus | CYTOCHROME-C RELEASE | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | CASPASE-8 | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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