Detailed Information

Cited 61 time in webofscience Cited 63 time in scopus
Metadata Downloads

Bax-dependent apoptosis induced by ceramide in HL-60 cells

Full metadata record
DC Field Value Language
dc.contributor.authorKim, HJ-
dc.contributor.authorMun, JY-
dc.contributor.authorChun, YJ-
dc.contributor.authorChoi, KH-
dc.contributor.authorKim, MY-
dc.date.available2019-05-30T09:38:40Z-
dc.date.issued2001-09-
dc.identifier.issn0014-5793-
dc.identifier.issn1873-3468-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25183-
dc.description.abstractCeramide is an important lipid messenger involved in mediating a variety of cell functions including apoptosis. In this study, we show that antisense bax inhibits cytochrome c release, poly(ADP-ribose)polymerase cleavage and cell death induced by ceramide in HL-60 cells. In addition, ceramide induces translocation of Bax to mitochondria. The addition of the broad spectrum caspase inhibitor zVAD-fmk prevented ceramide-induced apoptotic cell death but did not inhibit translocation of Bax and mitochondrial cytochrome c release. Furthermore, ceramide inhibits the expression of the antiapoptotic protein Bcl-xL with an increase in the ratio of Bax to Bcl-xL. These data provide direct evidence that Bax plays an important role in regulating ceramide-induced apoptosis. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherELSEVIER SCIENCE BV-
dc.titleBax-dependent apoptosis induced by ceramide in HL-60 cells-
dc.typeArticle-
dc.identifier.doi10.1016/S0014-5793(01)02836-8-
dc.identifier.bibliographicCitationFEBS LETTERS, v.505, no.2, pp 264 - 268-
dc.description.isOpenAccessN-
dc.identifier.wosid000171125800013-
dc.identifier.scopusid2-s2.0-0035860393-
dc.citation.endPage268-
dc.citation.number2-
dc.citation.startPage264-
dc.citation.titleFEBS LETTERS-
dc.citation.volume505-
dc.type.docTypeArticle-
dc.publisher.location네델란드-
dc.subject.keywordAuthorceramide-
dc.subject.keywordAuthorBax-
dc.subject.keywordAuthorBcl-xL-
dc.subject.keywordAuthorapoptosis-
dc.subject.keywordAuthorcaspase-
dc.subject.keywordPlusCYTOCHROME-C RELEASE-
dc.subject.keywordPlusNECROSIS-FACTOR-ALPHA-
dc.subject.keywordPlusMITOCHONDRIA-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusBCL-2-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusINVOLVEMENT-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusCASPASE-8-
dc.subject.keywordPlusMECHANISM-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Pharmacy > School of Pharmacy > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Chun, Young Jin photo

Chun, Young Jin
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE