Involvement of p38 mitogen-activated protein kinase and apoptosis signal-regulating kinase-1 in nitric oxide-induced cell death in PC12 cells
DC Field | Value | Language |
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dc.contributor.author | Han, Ok-Jin | - |
dc.contributor.author | Joe, Keun Ho | - |
dc.contributor.author | Kim, Seong Won | - |
dc.contributor.author | Lee, Hee Sung | - |
dc.contributor.author | Kwon, Nyoun Soo | - |
dc.contributor.author | Baek, Kwang Jin | - |
dc.contributor.author | Yun, Hye-Young | - |
dc.date.available | 2019-05-30T09:39:46Z | - |
dc.date.issued | 2001-05 | - |
dc.identifier.issn | 0364-3190 | - |
dc.identifier.issn | 1573-6903 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25221 | - |
dc.description.abstract | Although nitric oxide (NO) plays key signaling roles in the nervous systems, excess NO leads to cell death. In this study, the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and apoptosis signal-regulating kinase-1 (ASK1) in NO-induced cell death was investigated in PC12 cells. NO donor transiently activated p38 MAPK in the wild type parental PC12 cells, whereas the p38 MAPK activation was abolished in NO-resistant PC12 cells (PC12-NO-R). p38 MAPK inhibitors protected the cells against NO-induced death, whereas the inhibitors were not significantly protective against the cytotoxicity of reactive oxygen species. Stable transfection with dominant negative p38 MAPK mutant reduced NO-induced cell death. Stable transfection with dominant negative mutant of ASK1 attenuated NO-stimulated activation of p38 MAPK and decreased NO-induced cell death. These results suggest that p38 MAPK and its upstream regulator ASK1 are involved in NO-induced PC12 cell death. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KLUWER ACADEMIC/PLENUM PUBL | - |
dc.title | Involvement of p38 mitogen-activated protein kinase and apoptosis signal-regulating kinase-1 in nitric oxide-induced cell death in PC12 cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1023/A:1010917129951 | - |
dc.identifier.bibliographicCitation | NEUROCHEMICAL RESEARCH, v.26, no.5, pp 525 - 532 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000170439500012 | - |
dc.identifier.scopusid | 2-s2.0-0034885305 | - |
dc.citation.endPage | 532 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 525 | - |
dc.citation.title | NEUROCHEMICAL RESEARCH | - |
dc.citation.volume | 26 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | p38 MAPK | - |
dc.subject.keywordAuthor | ASK1 | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | PC12 | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | NEURONS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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