The involvement of phospholipase A(2) in ethanol-induced gastric muscle contraction
DC Field | Value | Language |
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dc.contributor.author | Sim, SS | - |
dc.contributor.author | Choi, JC | - |
dc.contributor.author | Min, DS | - |
dc.contributor.author | Rhie, DJ | - |
dc.contributor.author | Yoon, SH | - |
dc.contributor.author | Hahn, SJ | - |
dc.contributor.author | Kim, CJ | - |
dc.contributor.author | Kim, MS | - |
dc.contributor.author | Jo, YH | - |
dc.date.available | 2019-05-30T09:40:18Z | - |
dc.date.issued | 2001-02 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25240 | - |
dc.description.abstract | To understand the underlying mechanism of ethanol in tonic contraction, the effect of ethanol on phospholipase A(2) and phospholipase C activities and the effects of phospholipase inhibitors on ethanol-induced contraction of cat gastric smooth muscle were tested. Circular muscle strips (2.0 x 0.2 cm) obtained from the fundus of cat stomach were used to measure isometric contraction. Ethanol elicited tonic contraction and activated phospholipase A(2) activity in a dose-dependent manner. Phospholipase A(2) inhibitors, manoalide (0.1-10 muM) and oleyloxyethyl phosphorylcholine (1-10 muM), significantly inhibited ethanol-induced contraction. Furthermore, 342 mM ethanol-induced contraction was significantly inhibited by cyclooxygenase inhibitors, ibuprofen (10-100 muM) and indomethacin (10-100 muM), but not by lipoxygenase inhibitors. On the other hand phospholipase C inhibitors had no effect on ethanol-induced contraction, indicating that phospholipase C is not involved in ethanol-induced contraction. It is suggested from the above results that ethanol-induced contraction in cat gastric smooth muscle is, in part, mediated by phospholipase A(2) and cyclooxygenase pathways. (C) 2001 Elsevier Science B.V. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | The involvement of phospholipase A(2) in ethanol-induced gastric muscle contraction | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0014-2999(01)00753-1 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.413, no.2-3, pp 281 - 285 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000167270200019 | - |
dc.identifier.scopusid | 2-s2.0-0035895541 | - |
dc.citation.endPage | 285 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 281 | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 413 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | cyclooxygenase | - |
dc.subject.keywordAuthor | ethanol | - |
dc.subject.keywordAuthor | lipoxygenase | - |
dc.subject.keywordAuthor | phospholipase A(2) | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | smooth muscle | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | ETHYL-ALCOHOL | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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