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Synthesis of 6-exomethylenepenams as beta-lactamase inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Im, C | - |
| dc.contributor.author | Oh, JS | - |
| dc.contributor.author | Yim, CB | - |
| dc.date.available | 2019-05-30T10:36:46Z | - |
| dc.date.issued | 1999-02 | - |
| dc.identifier.issn | 0253-6269 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25430 | - |
| dc.description.abstract | The 6,6-dibromopenam (6) was treated with CH3MgBr and carbaldehyde 5 to afford the hydroxy compound 7, which was reacted with acetic anhydride to give acetoxy compound 8. The deacetobromination of 8 with zinc and acetic acid gave 6-exomethylenepenams, E-isomer 10 and Z-isomer 9, which was oxidized to sulfone 11 by m-CPBA. The p-methoxybenzyl compounds were deprotected by AlCl3 and neutralized to give the sodium salts 12, 13 and 14. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | PHARMACEUTICAL SOCIETY KOREA | - |
| dc.title | Synthesis of 6-exomethylenepenams as beta-lactamase inhibitors | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1007/BF02976438 | - |
| dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.22, no.1, pp 68 - 71 | - |
| dc.description.isOpenAccess | N | - |
| dc.identifier.wosid | 000078785400012 | - |
| dc.identifier.scopusid | 2-s2.0-0033073894 | - |
| dc.citation.endPage | 71 | - |
| dc.citation.number | 1 | - |
| dc.citation.startPage | 68 | - |
| dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
| dc.citation.volume | 22 | - |
| dc.type.docType | Article | - |
| dc.publisher.location | 대한민국 | - |
| dc.subject.keywordAuthor | triazole | - |
| dc.subject.keywordAuthor | 6-exomethylenepenam | - |
| dc.subject.keywordAuthor | beta-lactamase inhibitors | - |
| dc.subject.keywordPlus | BROAD-SPECTRUM INHIBITORS | - |
| dc.subject.keywordPlus | 6-(SUBSTITUTED METHYLENE)PENEMS | - |
| dc.subject.keywordPlus | DERIVATIVES | - |
| dc.subject.keywordPlus | ACID | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
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