Differential effects of nitric oxide synthase inhibitors in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J.-H. | - |
dc.contributor.author | Chang Yell Shin | - |
dc.contributor.author | Bong Su Kang | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Kyeong Bum Choi | - |
dc.contributor.author | Young Sil Min | - |
dc.contributor.author | Jin Hak Kim | - |
dc.contributor.author | In Hoi Huh | - |
dc.contributor.author | Uy Dong Sohn | - |
dc.date.available | 2019-06-10T09:30:50Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25589 | - |
dc.description.abstract | We investigated the action of NOS inhibitors on NOS in rots. Both of nitric oxide synthase inhibitors, N(G)-monomethyl-L-arginine (L-NMMA, 3 μM) or N(G)-nitro-L-arginine methylester (L-NAME, 30 μM), augmented phenylephrine (PE, 10-7 M)-induced contraction which was inhibited by acetylcholine (ACh) in rat thoracic aorta. This augmentation by L-NAME or L- NMMA was attenuated with the treatment of NO precursor, arginine. ACh, however, decreased the augmentation induced by L-NMMA, but not by L-NAME. Superoxide dismutase (SOD, 50 u/ml) potentiated an inhibitory effect of ACh on the PE (10-7 M)-induced contraction. It has been known that platelet activating factor itself induces iNOS. Platelet activating factor (PAF, 10- 7 M) inhibited PE (10-7 M)-induced contraction. Pretreatment with L-NMMA (30 mM) or L-NAME (30 mM) significantly blocked the inhibitory action of PAF on PE-induced contraction. L-NMMA (100 mM) or L-NAME (100 mM) reduced nerve conduction velocity (NCV) relevant to nNOS in rat sciatic nerve. ACh attenuated the reduction of NCV by L-NMMA-, but not by L-NAME-induced reduction of NCV. These results suggest that L-NMMA and/or L-NAME have different action on three types of NOS in rats. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Differential effects of nitric oxide synthase inhibitors in rats | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Korean Journal of Physiology and Pharmacology, v.4, no.2, pp 99 - 104 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-0034042364 | - |
dc.citation.endPage | 104 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 99 | - |
dc.citation.title | Korean Journal of Physiology and Pharmacology | - |
dc.citation.volume | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | N(G)-monomethyl-L-arginine | - |
dc.subject.keywordAuthor | N(G)- nitro-L-arginine methylester | - |
dc.subject.keywordAuthor | Nerve conduction velocity | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Platelet activating factor | - |
dc.subject.keywordAuthor | Superoxide anion | - |
dc.subject.keywordPlus | acetylcholine | - |
dc.subject.keywordPlus | n(g) methylarginine | - |
dc.subject.keywordPlus | n(g) nitroarginine methyl ester | - |
dc.subject.keywordPlus | nitric oxide synthase inhibitor | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | aorta constriction | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | drug selectivity | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | nerve conduction | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | sciatic nerve | - |
dc.subject.keywordPlus | vascular smooth muscle | - |
dc.subject.keywordPlus | vasodilatation | - |
dc.description.journalRegisteredClass | scopus | - |
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