Effect of C1 esterase inhibitor on the cardiac dysfunction following ischemia and reperfusion in the isolated perfused rat heart
DC Field | Value | Language |
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dc.contributor.author | Lee, Geon-Yong | - |
dc.contributor.author | Shin, Yong-Kyoo | - |
dc.contributor.author | Jang, Yoon-Young | - |
dc.contributor.author | Song, Jin-Ho | - |
dc.contributor.author | Kim, Dae-Joong | - |
dc.date.available | 2019-06-10T09:31:24Z | - |
dc.date.issued | 1999-12 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25602 | - |
dc.description.abstract | Complement-mediated neutrophil activation has been hypothesized to be an important mechanism of reperfusion injury. It has been proposed that C1 esterase inhibitor (C1 INH) may prevent the complement-dependent activation of polymorphonuclear leukocytes (PMNs) that occurs within postischemic myocardium. Therefore, The effect of C1 INH was examined in neutrophil dependent isolated perfused rat heart model of ischemia (I) (20 min) and reperfusion (R) (45 min). Administration of C1 INH (5 mg/Kg) to I/R hearts in the presence of PMNs (100 x 106) and homologous plasma improved coronary flow and preserved cardiac contractile function (p <0.001) in comparison to those I/R hearts receiving only vehicle. In addition, C1 INH significantly (p<0.001) reduced PMN accumulation in the ischemic myocardium as evidenced by an attenuation in myeloperoxidase activity. These findings demonstrate the C1 INH is a potent and effective cardioprotective agent inhibits leukocyte- endothelial interaction and preserves cardiac contractile function and coronary perfusion following myocardial ischemia and reperfusion. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한약리학회 | - |
dc.title | Effect of C1 esterase inhibitor on the cardiac dysfunction following ischemia and reperfusion in the isolated perfused rat heart | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | The Korean Journal of Physiology & Pharmacology, v.3, no.6, pp 579 - 586 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-0033384484 | - |
dc.citation.endPage | 586 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 579 | - |
dc.citation.title | The Korean Journal of Physiology & Pharmacology | - |
dc.citation.volume | 3 | - |
dc.identifier.url | https://www.kjpp.net/journal/view.html?volume=3&number=6&spage=579 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Complement esterase inhibitor (C1 INH) | - |
dc.subject.keywordAuthor | Ischemia/Reperfusion | - |
dc.subject.keywordAuthor | PMNs | - |
dc.subject.keywordAuthor | Rat heart | - |
dc.subject.keywordPlus | complement component C1s inhibitor | - |
dc.subject.keywordPlus | myeloperoxidase | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | coronary artery blood flow | - |
dc.subject.keywordPlus | drug efficacy | - |
dc.subject.keywordPlus | drug potency | - |
dc.subject.keywordPlus | enzyme activity | - |
dc.subject.keywordPlus | heart muscle contractility | - |
dc.subject.keywordPlus | heart muscle ischemia | - |
dc.subject.keywordPlus | heart protection | - |
dc.subject.keywordPlus | inflammatory infiltrate | - |
dc.subject.keywordPlus | isolated heart | - |
dc.subject.keywordPlus | leukocyte activation | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | neutrophil | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | pathogenesis | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | reperfusion injury | - |
dc.description.journalRegisteredClass | scopus | - |
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