Subcutaneous four-week repeated dose toxicity studies of rice cell-derived recombinant human granulocyte-macrophage colony stimulating factor in rats
DC Field | Value | Language |
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dc.contributor.author | Ji, J.E. | - |
dc.contributor.author | Lee, J.M. | - |
dc.contributor.author | Choi, J.M. | - |
dc.contributor.author | Choi, Y.H. | - |
dc.contributor.author | Kim, E.K. | - |
dc.contributor.author | Chu, S.J. | - |
dc.contributor.author | Kim, S.K. | - |
dc.contributor.author | Ahn, K.H. | - |
dc.contributor.author | Lee, D.H. | - |
dc.contributor.author | Kim, H.H. | - |
dc.contributor.author | Han, K. | - |
dc.contributor.author | Kim, D.K. | - |
dc.date.available | 2019-06-11T08:33:11Z | - |
dc.date.issued | 2008-12 | - |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.issn | 2234-2753 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25653 | - |
dc.description.abstract | Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produced in transgenic rice cell suspension culture, termed rhGM-CSF. In the present study, we examined the repeated dose toxicity of rhGM-CSF in SD rats. The repeated dose toxicity study was performed at each dose of 50 and 200 μg/kg subcutaneous administration of rhGM-CSF everyday for 28-days period. The results did not show any changes in food and water intake. There were also no significant changes in both body and organ weights between the control and the tested groups. The hematological and blood biochemical parameters were statistically not different in all groups. These results suggest that rhGM-CSF may show no repeated dose toxicity in SD rats under the conditions. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국독성학회 | - |
dc.title | Subcutaneous four-week repeated dose toxicity studies of rice cell-derived recombinant human granulocyte-macrophage colony stimulating factor in rats | - |
dc.title.alternative | Subcutaneous Four-Week Repeated Dose Toxicity Studies of Rice Cell-Derived Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.5487/TR.2008.24.4.315 | - |
dc.identifier.bibliographicCitation | Toxicological Research, v.24, no.4, pp 315 - 320 | - |
dc.identifier.kciid | ART001293693 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84880633943 | - |
dc.citation.endPage | 320 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 315 | - |
dc.citation.title | Toxicological Research | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Recombinant hGM-CSF | - |
dc.subject.keywordAuthor | Repeated dose toxicity | - |
dc.subject.keywordAuthor | Rice cells | - |
dc.subject.keywordAuthor | SD rats | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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