Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion
DC Field | Value | Language |
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dc.contributor.author | Lee, Jonghwi | - |
dc.contributor.author | Lee, Soo-Jeong | - |
dc.contributor.author | Choi, Ji-Yeun | - |
dc.contributor.author | Yoo, Ji Youn | - |
dc.contributor.author | Ahn, Cheol-Hee | - |
dc.date.available | 2019-06-26T01:21:03Z | - |
dc.date.issued | 2005-04 | - |
dc.identifier.issn | 0928-0987 | - |
dc.identifier.issn | 1879-0720 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/26144 | - |
dc.description.abstract | The recent advance of particle size engineering in nanometer ranges has widened the formulation opportunities of relatively water-insoluble drugs. However, the 'nanoformulation' suffers from a lack of systematic understanding about the requirements of polymeric stabilizers. Furthermore, the polymers that can be used for the preparation of nanocrystals are so limited that finding a proper stabilizer for a given formulation is often difficult. In this study, amino acid copolymers whose properties can systematically be tailored are developed, and their morphological and compositional effects are investigated. Copolymers containing lysine (K) as their hydrophilic segments, and phenylalanine (F) or leucine (L) as their hydrophobic segments successfully produce stable nanocrystals (200-300 nm) in water, while copolymers of K and alanine (A) could not generate nanosized particles. Not the morphology but the hydrophobicity of copolymers seems to be a critical parameter in the preparation of drug nanocrystals by wet comminution. The effective stabilization performance of copolymers requires the hydrophobic moiety content to be higher than 15 mol%. Comminution for only 5 min is long enough for nanocrystal preparation, and the crystallinity of drug is found intact after the processing. © 2005 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier | - |
dc.title | Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejps.2004.12.010 | - |
dc.identifier.bibliographicCitation | European Journal of Pharmaceutical Sciences, v.24, no.5, pp 441 - 449 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-15244348244 | - |
dc.citation.endPage | 449 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 441 | - |
dc.citation.title | European Journal of Pharmaceutical Sciences | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Dispersion | - |
dc.subject.keywordAuthor | Insoluble drug | - |
dc.subject.keywordAuthor | Nanocrystals | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Particle engineering | - |
dc.subject.keywordAuthor | Particle size | - |
dc.subject.keywordPlus | amino acid derivative | - |
dc.subject.keywordPlus | copolymer | - |
dc.subject.keywordPlus | leucine | - |
dc.subject.keywordPlus | lysine | - |
dc.subject.keywordPlus | nanoparticle | - |
dc.subject.keywordPlus | naproxen | - |
dc.subject.keywordPlus | phenylalanine | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | chemical composition | - |
dc.subject.keywordPlus | chemical engineering | - |
dc.subject.keywordPlus | dispersion | - |
dc.subject.keywordPlus | drug stability | - |
dc.subject.keywordPlus | hydrophilicity | - |
dc.subject.keywordPlus | morphology | - |
dc.subject.keywordPlus | particle size | - |
dc.subject.keywordPlus | priority journal | - |
dc.description.journalRegisteredClass | scopus | - |
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