The improvement of learning and memory ability of normal persons by BF-7
- Authors
- Lee, Sang Hyung; Kim, Yong Sik; Kang, Yong Koo; Kwon, Oh Sang; Shin, Yong Kyoo; Song, Jin Ho; Lee, Moo Yeol; Lee, Kwang-Gil; Yeo, Joo-Hong; Lee, Won Bok; Lee, Tae Jin; Kim, Sung Su
- Issue Date
- Dec-2004
- Publisher
- 대한약리학회
- Keywords
- Acetylcholine; BF-7; Brain; Learning and memory; Neuroprotection
- Citation
- The Korean Journal of Physiology & Pharmacology, v.8, no.6, pp 307 - 312
- Pages
- 6
- Journal Title
- The Korean Journal of Physiology & Pharmacology
- Volume
- 8
- Number
- 6
- Start Page
- 307
- End Page
- 312
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/26216
- ISSN
- 1226-4512
2093-3827
- Abstract
- To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
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