Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Emami, F. | - |
dc.contributor.author | Mostafavi Yazdi, S.J. | - |
dc.contributor.author | Na, D.H. | - |
dc.date.available | 2019-06-26T01:30:30Z | - |
dc.date.issued | 2019-07-01 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.issn | 2093-6214 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/26335 | - |
dc.description.abstract | Background: Pulmonary route is an attractive target for both systemic and local drug delivery, with the advantages of a large surface area, rich blood supply, and absence of first-pass metabolism. Numerous polymeric micro/nanoparticles have been designed and studied for controlled and targeted drug delivery to the lung. Area covered: Among the natural and synthetic polymers for polymeric particles, poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) have been widely used for the delivery of anti-cancer agents, anti-inflammatory drugs, vaccines, peptides, and proteins because of their highly biocompatible and biodegradable properties. This review focuses on the characteristics of PLA/PLGA particles as carriers of drugs for efficient delivery to the lung. Furthermore, the manufacturing techniques of the polymeric particles, and their applications for inhalation therapy were discussed. Expert opinion: Compared to other carriers including liposomes, PLA/PLGA particles present a high structural integrity providing enhanced stability, higher drug loading, and prolonged drug release. Adequately designed and engineered polymeric particles can contribute to a desirable pulmonary drug delivery characterized by a sustained drug release, prolonged drug action, reduction in the therapeutic dose, and improved patient compliance. © 2019, The Korean Society of Pharmaceutical Sciences and Technology. | - |
dc.format.extent | 16 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Netherlands | - |
dc.title | Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery | - |
dc.title.alternative | Poly(lactic acid)/poly(lactic‑co‑glycolic acid) particulate carriers for pulmonary drug delivery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s40005-019-00443-1 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical Investigation, v.49, no.4, pp 427 - 442 | - |
dc.identifier.kciid | ART002487899 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85064705597 | - |
dc.citation.endPage | 442 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 427 | - |
dc.citation.title | Journal of Pharmaceutical Investigation | - |
dc.citation.volume | 49 | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Microparticles | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Poly(lactic acid) | - |
dc.subject.keywordAuthor | Poly(lactic-co-glycolic acid) | - |
dc.subject.keywordAuthor | Pulmonary drug delivery | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.