Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment
DC Field | Value | Language |
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dc.contributor.author | Kim, S. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Jo, E.-S. | - |
dc.contributor.author | Gil, K. | - |
dc.contributor.author | Kim, N.-Y. | - |
dc.contributor.author | Park, J.S. | - |
dc.contributor.author | Park, D. | - |
dc.contributor.author | Park, S.-Y. | - |
dc.contributor.author | Hwang, K.W. | - |
dc.date.available | 2019-06-26T01:33:55Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.issn | 2214-9414 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/26375 | - |
dc.description.abstract | We aimed to investigate possible anticancer effects of Amtak-ssamchae (a newly bred cabbage line containing more carotenoids) in an in vitro pancreatic-tumor cell model and an in vivo model (Panc02 cells). In an in vitro assay, Amtak-ssamchae significantly reduced the viability of Panc02 cells relative to normal ssamchae. Furthermore, an Amtak-ssamchae extract significantly reduced the tumor size in mice inoculated with Panc02 cells, and this effect was accompanied by changes in the cell population in/near the tumor and spleen. Treatment with the extract of the new cabbage line blocked regulatory-T-cell recruitment, which is known as the main pathological mechanism of action of pancreatic cancer to avoid host immunity. Additionally, Amtak-ssamchae (not the normal line) contained β-carotene (at 27.9 ± 2.1 μg/g). Thus, we suggest that the Amtak-ssamchae extract could be a resource for natural supplements and functional foods for combating pancreatic cancer. © 2019 Elsevier Ltd | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jff.2019.05.006 | - |
dc.identifier.bibliographicCitation | Journal of Functional Foods, v.58, pp 301 - 310 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000471208500033 | - |
dc.identifier.scopusid | 2-s2.0-85065538416 | - |
dc.citation.endPage | 310 | - |
dc.citation.startPage | 301 | - |
dc.citation.title | Journal of Functional Foods | - |
dc.citation.volume | 58 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Amtak-ssamchae | - |
dc.subject.keywordAuthor | Chemokine receptor | - |
dc.subject.keywordAuthor | Chemokine receptor ligand | - |
dc.subject.keywordAuthor | Pancreatic cancer | - |
dc.subject.keywordAuthor | Regulatory T cell | - |
dc.subject.keywordAuthor | β-carotene | - |
dc.subject.keywordPlus | BETA-CAROTENE | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | INFILTRATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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