Polydiacetylene Single-Walled Carbon Nanotubes Nano-Hybrid for Cellular Imaging Applications
- Authors
- Yang, Kwang Suk; Yun, Ji Sun; Kim, Jin Chul; Min, Jungsun; Park, Tae Jung; Ahn, Jeong Keun; Kim, Do Hyun
- Issue Date
- Jan-2012
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Single-Walled Carbon Nanotubes; Polydiacetylene; Near-Infrared Fluorescence; Molecular Imaging; Cell Viability; Toxicity
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.12, no.1, pp 377 - 385
- Pages
- 9
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 12
- Number
- 1
- Start Page
- 377
- End Page
- 385
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/27718
- DOI
- 10.1166/jnn.2012.5394
- ISSN
- 1533-4880
1533-4899
- Abstract
- The functionalization of single-walled carbon nanotubes (SWCNTs) by forming self-assembled supramolecular structure of 10,12-pentacosadiynoic acid (PCDA) on the carbon nanotube wall is reported. PCDA assemblies on SWCNTs (PCDA/SWCNTs) were polymerized by UV irradiation to extensively conjugated polydiacetylene (PDA). PDA/SWCNT was identified by absorption and emission spectroscopy, scanning and transmission electron microscopies (SEM and TEM) and atomic force microscopy (AFM). PDA/SCWNTs showed strong near-infrared (NIR) fluorescence caused by fluorescence resonance energy transfer (FRET) between PDA network and semiconducting SWCNT core. The micro-patterning of biotinylated PDA/SWCNT with FITC-avidin on biotinylated glass surface demonstrated the potential application for a bio-sensing device. Furthermore, the biocompatibility for mammalian cancer cells was tested by viability experiments, which revealed that the PDA/SWCNTs had very low toxicity below 31.3 mg/L in terms of pristine SWCNTs concentration. Also, PDA/SWCNTs inside the cells can be observed by NIR microscopy. This unique modular method of preparation can contribute to diverse functionalities for practical applications in various non-invasive cellular imaging.
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