와파린의 HPLC 분석법 및 한국인에서의 약동학적 특징

Abstract

Warfarin is a widely used oral anticoagulant agent used to treat thromboembolic disease. The purpose of this study was to develop the efficient assay method of warfarin sodium in human plasma and to assess the pharmacokinetic profile of the warfarin in healthy Korean volunteers. The pharmacokinetics of warfarin administered orally was evaluated after a dose of 10 mg. Warfarin in plasma was assayed using a specific HPLC method with UV absorbance at 304 nm. AUC was 46.33±9.95㎍/ml·hr, Cmax 1.22±0.22㎍/ml , Tmax 2.50±1.41 hr and half-life 43.49±4.33 hr. Tmax was slightly shorter than that in Caucasian (3~9 hr), whereas the half-life was longer than that in Caucasian (10~45 hr, mean: 36 hr). These results suggest that warfarin may have a longer duration in Korea than in Caucasian.