Urethane으로 유발된 생쥐 폐샘암종 발생과정에서 세포주기 관련인자 (Cyclin D1, p21, and p27)에 대한 비소의 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이성혁 | - |
dc.contributor.author | 정지훈 | - |
dc.contributor.author | 견종만 | - |
dc.contributor.author | 박언섭 | - |
dc.date.available | 2019-07-18T03:06:55Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0377-9556 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/29168 | - |
dc.description.abstract | The present study investigated an effect of arsenic trioxide on the urethane-induced lung carcinogenesis in mice. To understand its carcinogenesis, we examined proliferating cell nuclear antigen (PCNA), apoptotic index as well as cell cycle-related proteins (cyclin D1, p21, and p27). Urethane was injected intraperitoneally in ICR mice, and then they were sacrificed at 5, 15, or 25 weeks following treatment of arsenic trioxide. Arsenic trioxide was given with tap water at a concentration of 1 mg/l (low-dose) and 5 mg/l (high-dose) for 25 weeks. During the carcinogenesis, sequential histological changes from hyperplasia to adenomas, and ultimately to overt carcinomas were noted. The development of hyperplasias, adenomas, and carcinomas in the lung were slightly increased by the treatment of low-dose arsenic trioxide. However, there is no correlation between dose and tumor multiplicity. The administration of low-dose arsenic trioxide, significantly increased the tumor size. The proliferative index observed on 5 weeks after significantly increased. Cyclin D1 and p21 protein, cell cycle related proteins, were more significantly increased in hyperplasia and adenoma in low dose arsenic treated group than urethane alone group. The p27 protein expression did not show any significantly changes with arsenic treated or untreated group. Low dose exposure to arsenic trioxide resulted in increased expression of cyclin D1 and p21 protein. The present results indicate that low-dose treatment of arsenic trioxide, but not high dose of it, partly modulate the cellular proliferation, cyclin D1, and p21 protein expression, and that this effect may contribute to accelerated development of lung adenocarcinomas in urethane-induced mice. | - |
dc.format.extent | 9 | - |
dc.publisher | 대한약학회 | - |
dc.title | Urethane으로 유발된 생쥐 폐샘암종 발생과정에서 세포주기 관련인자 (Cyclin D1, p21, and p27)에 대한 비소의 효과 | - |
dc.title.alternative | Effects of Arsenic Trioxide on Cell Cycle Related Proteins (Cyclin D1, p21, p27) Expression DuringUrethane-induced Lung Carcinogenesis in Mice | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 약 학 회 지, v.50, no.2, pp 84 - 92 | - |
dc.identifier.kciid | ART001115140 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 92 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 84 | - |
dc.citation.title | 약 학 회 지 | - |
dc.citation.volume | 50 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | lung carcinogenesis | - |
dc.subject.keywordAuthor | urethane | - |
dc.subject.keywordAuthor | arsenic trioxide | - |
dc.subject.keywordAuthor | cell cycle related proteins | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.