오미자 활성성분 DDB의 NF-κB 신호 전달 및 염증물질 발현 조절.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 주성수 | - |
dc.contributor.author | 유영민 | - |
dc.contributor.author | 원태준 | - |
dc.contributor.author | 김민정 | - |
dc.contributor.author | 이선구 | - |
dc.contributor.author | 황광우 | - |
dc.contributor.author | 이도익 | - |
dc.date.available | 2019-07-18T03:59:47Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.issn | 2092-6685 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/29251 | - |
dc.description.abstract | Background: Chronic inflammation in the brain has known to be associated with the development of a various neurological diseases including dementia. In general, the characteristic of neuro-inflammation is the activated microglia over the brain where the pathogenesis occurs. Pro-inflammatory repertoires, interleukin-1β (IL-1β) and nitric oxide (NO), are the main causes of neuro-degenerative disease, particularly in Alzheimer's disease (AD) which is caused by neuronal destruction. Those pro-inflammatory repertoires may lead the brain to chronic inflammatory status, and thus we hypothesized that chronic inflammation would be inhibited when pro-inflammatory repertoires are to be well controlled by inactivating the signal transduction associated with inflammation. Methods: In the present study, we examined whether biphenyl dimethyl dicarboxylate (DDB), an active compound from Schizandra chinensis Baillon, inhibits the NO production by a direct method using Griess reagent and by RT-PCR in the gene expression of inducible nitric oxide synthase (iNOS) and IL-1β. Western blots were also used for the analysis of NF-κB and IκB. Results: In the study, we found that DDB effectively inhibited IL-1β as well as NO production in BV-2 microglial cell, and the translocation of NF-κB was comparably inhibited in the presence of DDB comparing those to the positive control, lipopolysaccharide. Conclusion: The data suggested that the DDB from Schizandra chinensis Baillon may play an effective role in inhibiting the pro-inflammatory repertoires which may cause neurodegeneration and the results imply that the compound suppresses a cue signal of the microglial activation which can induce the brain pathogenesis such as Alzheimer's disease. (Immune Network 2006;6(1):27- 32) | - |
dc.format.extent | 6 | - |
dc.publisher | 대한면역학회 | - |
dc.title | 오미자 활성성분 DDB의 NF-κB 신호 전달 및 염증물질 발현 조절. | - |
dc.title.alternative | Regulation of Inflammatory Repertoires and NF-κB Signal Transduction by DDB, an Active Compound from Schizandra Chinensis Baillon | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Immune Network, v.6, no.1, pp 27 - 32 | - |
dc.identifier.kciid | ART001177100 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 27 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 6 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.subject.keywordAuthor | IL-1β | - |
dc.subject.keywordAuthor | biphenyl dimethyl dicarboxylate | - |
dc.subject.keywordAuthor | alzheimer's disease | - |
dc.description.journalRegisteredClass | kciCandi | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.