대장직장암에서 Survivin과 HSP90 단백발현과 예후인자와의 관계
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김택현 | - |
dc.contributor.author | 이태진 | - |
dc.contributor.author | 김범규 | - |
dc.contributor.author | 차성재 | - |
dc.contributor.author | 박성준 | - |
dc.contributor.author | 임현묵 | - |
dc.contributor.author | 박성일 | - |
dc.date.available | 2019-07-18T04:00:08Z | - |
dc.date.issued | 2006-02 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.issn | 2288--679 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/29258 | - |
dc.description.abstract | Purpose: Survivin is an inhibitor of apoptosis protein and it is overexpressed in most human cancers. Recent data demonstrated that survivin-HSP90 complex regulate apoptosis. We assessed expression of survivin and HSP90 by using immunohistochemistry with colorectal cancer tissue and correlate it with clinicopathologic prognostic parameters. Methods: Using immunohistochemistry, survivin and HSP90 expression were evaluated on paraffin sections of fifty-six colorectal carcinomas. Various clinicopathologic parameters including histologic differentiation grade, T-stage, nodal metastasis, stage were obtained from pathologic records. Results: Survivin expression were observed in 30 cases (53.6%). The expression of survivin showed no statistically significant correlation with histologic differentiation grade, T-stage, nodal metastasis, stage. HSP90 expression were observed in 31 cases (55.4%). The expression of HSP90 showed a statistically significant correlation with histologic differentiation grade (P=0.035) and stage (P=0.017). There were a significant correlation between survivin expression and HSP90 expression (P=0.018). Conclusion: Survivin and HSP90 was expressed in colorectal cancer. The expression of HSP90 correlates with histologic differentiation grade, stage. The above results suggest that HSP90 could be a prognostic marker of poor outcome in colorectal carcinoma. (J Korean Surg Soc 2006;70: 113-119) | - |
dc.format.extent | 7 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한외과학회 | - |
dc.title | 대장직장암에서 Survivin과 HSP90 단백발현과 예후인자와의 관계 | - |
dc.title.alternative | Expression of Survivin and HSP90 in Colorectal Cancer and its Relationship with Clinicopathologic Factors | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한외과학회지, v.70, no.2, pp 113 - 119 | - |
dc.identifier.kciid | ART001150255 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 119 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 113 | - |
dc.citation.title | 대한외과학회지 | - |
dc.citation.volume | 70 | - |
dc.identifier.url | https://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE01896817 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Survivin | - |
dc.subject.keywordAuthor | HSP90 | - |
dc.subject.keywordAuthor | Colorectal cancer | - |
dc.subject.keywordAuthor | 대장직장암 | - |
dc.description.journalRegisteredClass | kci | - |
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