구지뽕나무 잎의 항산화 성분Anti-oxidant Compounds of Cudrania tricuspidata Leaves
- Authors
- 전인주; 이성완; 차자현; 한정훈; 황완균
- Issue Date
- 2005
- Publisher
- 대한약학회
- Keywords
- Cudrania tricuspidata Bereau; DPPH method; TBARS assay; quercetin glycoside; kaempferol glycoside
- Citation
- 약 학 회 지, v.49, no.5, pp 416 - 421
- Pages
- 6
- Journal Title
- 약 학 회 지
- Volume
- 49
- Number
- 5
- Start Page
- 416
- End Page
- 421
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/29487
- ISSN
- 0377-9556
- Abstract
- Cudrania tricuspidata Bereau (Moraceae) have been used for anti-inflammatory, anti-hepatotoxic, anti-hypertensive and anti-diabetic activities. In order to investigate the efficacy of antioxidant activity, the bio-activity guided fraction and isolation of Biologically active substance were performed. H2O, 30%, 60%, 100% MeOH and acetone fractions were examined on the antioxidant activity by DPPH method. It was shown that 30%, 60%, 100% MeOH fractions have significantly antioxidant activity. From 30% MeOH fraction, two dihydroflavonoid glycosides dihydroquercetin 7-O-β-D-glucopyranoside (I), dihydrokaempferol 7-O-β-D-glucopyranoside (V) were isolated and 60% MeOH fraction, six flavonoids including quercetin 3-O-α-L-rhamnopyranosyl(1→6)-β-D- glucopyranoside (II), quercetin 3-O-β-D-glucopyranoside (III), quercetin 7-O-β-D-glucopyranoside (IV), kaempferol 3-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (VI), kaempferol 3-O-β-D-glucopyranoside (VII), kaempferol 7-O-β-D-glucopyranoside (VIII) were isolated. To investigate the antioxidant activities of each compounds, we measured radical scavening activity with DPPH method and anti-lipid peroxidative efficacy on low density lipoprotein (LDL) with TBARS assay. Four compounds of quercetin glycosides (Ι, II, III, IV) showed significant antioxidant activity.
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