p53 Protein Expression Area as a Molecular Penumbra of Focal Cerebral Infarction in Rats
- Authors
- Hyun-Jong Hong; Seung-Won Park; 김영백; 민병국; 황성남; 석종식
- Issue Date
- 2005
- Publisher
- 대한신경외과학회
- Keywords
- Infarction Penumbra · Cerebral blood flow · Apoptosis · p53.
- Citation
- 대한신경외과학회지, v.38, no.4, pp 293 - 298
- Pages
- 6
- Journal Title
- 대한신경외과학회지
- Volume
- 38
- Number
- 4
- Start Page
- 293
- End Page
- 298
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/29497
- ISSN
- 1225-8245
1598-7876
- Abstract
- Objective : The authors investigate the spatial characteristics of apoptotic genes expressed around the focal cerebral infarction, and attempted to explain the penumbra with them.
Methods : A delayed focal cerebral infarction was created in twelve adult Sprague-Dawley rats. We performed the immunohistochemical staining for the apoptosis, bcl-2 and p53 proteins and measured the local cerebral blood flow (CBF) at the infarction core area and peri infarct area pre- and intra-operatively. The peri-infarct area was divided into six sectors by distance from the infarction border.
Results : The size (mm2) of apoptosis, bcl 2, and p53 areas were 3.1 1.2, 4.7 2.1, and 6.8 2.4, respectively. Apoptosis, bcl-2 or p53 positive cells were concentrated at the peri infarct area adjacent to the infarction core. Their numbers reduced peripherally, which was inversely proportional to the local CBF. The p53 area seems to overlap with and larger than the ischemic penumbra.
Conclusion : The p53 positive area provides a substitutive method defining the penumbra under the molecular base of knowledge.
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