하수오 지상부의 활성 성분Active Compounds from The Aerial Parts of Polygonum multiflorum Thunberg
- Authors
- 김진표; 김도훈; 김기은; 김진효; 정성희; 김성건; 황완균
- Issue Date
- 2006
- Publisher
- 대한약학회
- Citation
- 약 학 회 지, v.50, no.6, pp 351 - 357
- Pages
- 7
- Journal Title
- 약 학 회 지
- Volume
- 50
- Number
- 6
- Start Page
- 351
- End Page
- 357
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/29708
- ISSN
- 0377-9556
- Abstract
- aging in Korean folk medicine. Specially aerial parts has been used for insomnia and sedative agent. In order to investigatethe efficacy of antioxidant activity on these aerial parts, the bio-activity guided fraction and isolation of physiologically activesubstance were performed. H2O, 30%, 60%, 100% MeOH were examined antioxidant activity by DPPH method. It wasrevealed that 30%, 60% MeOH fractions have significantly antioxidant activity. From 60% MeOH fraction, six known fla-vonoid glycosides (quercetin, quercetin 3-O-β-D-galactopyranosyl-4'-O-glucopyranoside-3'-methylether, quercetin 3-O-α-L-rhamnopyranoside, quercetin 3-O-α-L-rhamnopyrano side-4'-methylether, quercetin 3-O-β-D-galactopyranoside, quercetin 3-O-β-D-glucopyranoside) and 3,4-dihydrocinnamic acid were isolated. To investigate the antioxidant activities of each com-pounds, we measured radical scavening activity with DPPH method and anti-lipid peroxidative efficacy on low density lipo-protein (LDL) with TBARS asay and anti-acetylcholinestrase activity with Ellman's Test. Four compounds (II, IV, VI, VII)of quercetin glycosides showed significant activity.Keywords . Polygonum multiflorum, DPPH method, TBARS assay, Ellman's Test, quercetin glycosides... (Polygonum multiflorum). .... (Polygonaceae).
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