Flavonoids의 약리작용(V)- 전기자극 및 과민반응으로 유발된 흰쥐 회장의 평활근수축에서 Flavones 및 Flavonols의 진경효과 -

Abstract

Some flavonoids have spasmolytic activities in various smooth muscles, but structure-activity relationships ontheir spasmolytic activity and its mechanism are unclear. In this study, effects of flavones (flavone and apigenin) and flavonolsin vivo and in vitro. In the electric stimulation-induced contraction, all of four flavonoids inhibited concentration-dependently the rat ileal smooth muscle contractioninduced by electric stimulation (10 mV, 0.1 cps, 0.1 msec duration), IC50 of quercetin, apigenin, flavone and rutin were0.98×10-5, 1.20×10-5, 1.55×10-5 and 1.85×10-5M, respectively. Flavonoids at a concentration of 2×10-5M also significantlyreaction, IC50 of quercetin, apigenin, flavone and rutin were 4.0×10-5, 7.5×10-5, 8.0×10-5 and 9.5×10-5M, respectively.These results indicated that flavones and flavonols inhibited the rat ileal smooth muscle contraction induced by electric stim-ulation because of their antagonism against acetylcholine and have spasmolytic activities on anaphylactic contraction whichmay be due to their mast cell-stabilizing activities. Furthermore, double bond of C2,3 in benzene ring of flavonoids may beanaphylactic reaction.Keywords . flavone, apigenin, quercetin, rutin, flavonoids, rat ileal smooth muscle contraction, anaphylactic contractionFlavonoids. ...... ..... . , . . .. .... .... .. phenol. .... ... ,1-5) .. ,6-13) .... ,14-18) .. ,19-22) .....23) . ....24,25). ...... .. . .. .... Bertelli and Mezzaxalma26).flavonoids .... amylkhellin, 2-phenylchrome, 3-methyl-chrome. pitresin. ... ... ..... ... ...... ..... , David Kidd27). flavonoids. ......