경도의 두부 외상 환자에서 S-100B 단백질의 진단적 유용성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김찬웅 | - |
dc.contributor.author | 김혜련 | - |
dc.contributor.author | 이미경 | - |
dc.date.available | 2019-07-24T03:59:58Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1226-4334 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/30313 | - |
dc.description.abstract | Purpose: Ninety percent of patients with minor head injury(MHI) who undergo computed tomography (CCT) under current clinical decision rules have normal scans. Serum concentrations of astroglial protein S-100B were recently found to provide useful information in such cases, but there is no clinical data in this country. We have investigated whether S-100B concentrations in alert patients with MHI can serve as an indicator of the need for an initial CCT scan. Methods: 40 patients with MHI and a control group of 54 healthy volunteers were enrolled in this prospective study. All patients with MHI had a CCT scan to confirm diagnosis, and blood was drawn from all study participants in order to measure S-100B concentrations. Data were analyzed using contingency table and a receiver operating characteristic (ROC) curve to determine the diagnostic value of S-100B. Results: Using a concentration cutoff of 0.12 g/L, patients with abnormal CCT findings were identified by S-100B measurement with a sensitivity level of 100% and a specificity level of 46%. S-100B concentrations for head injury patients with multiple trauma were increased more than for patients without combined injuries. Conclusion: Adding measurement of S-100B concentration to the clinical decision rules for a CCT scan in alert patients with MHI could allow a 46% reduction in scans in our study. However, before S-100B testing can be used clinically, larger domestic trials conforming to all appropriate ethical guidelines need to be conducted in the near future. | - |
dc.format.extent | 7 | - |
dc.publisher | 대한응급의학회 | - |
dc.title | 경도의 두부 외상 환자에서 S-100B 단백질의 진단적 유용성 | - |
dc.title.alternative | The Clinical Value of Serum S-100B Protein Measurements in Treating Minor Head Injury | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한응급의학회지, v.17, no.6, pp 574 - 580 | - |
dc.identifier.kciid | ART001154907 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 580 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 574 | - |
dc.citation.title | 대한응급의학회지 | - |
dc.citation.volume | 17 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | S-100 protein | - |
dc.subject.keywordAuthor | Computed tomography | - |
dc.subject.keywordAuthor | Minorhead injury | - |
dc.description.journalRegisteredClass | kci | - |
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