대장 직장암에서 D2-40을 이용한 림프계 미세 혈관 밀도와 혈관 내피세포 성장 인자-C의 단백 발현의 의미

Abstract

Purpose: Studying the prognostic factors of distant metastasis is quite important for predicting these patients’ prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors. Methods: 79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate. Results: The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the T- stage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer. Conclusion: The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer. (J Korean Surg Soc 2007;73:406-411)