프로톤펌프억제제 포함 표준요법 실패 후 Helicobacter pylori 감염 구제요법
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서영환 | - |
dc.contributor.author | 이수연 | - |
dc.contributor.author | 박범준 | - |
dc.contributor.author | 김형준 | - |
dc.contributor.author | 김재규 | - |
dc.date.available | 2019-07-31T01:59:11Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1738-9364 | - |
dc.identifier.issn | 2289-0769 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/30798 | - |
dc.description.abstract | Background/Aims : Proton pump inhibitor (PPI)-based standard triple therapy for Helicobacter pylori infection is widely used, but it has a considerable failure rate. The aim of this study was to evaluate the efficacy and tolerability of rescue therapies with a quadruple regimen and a rifabutin-based regimen for patients who experienced failure with PPI-based standard triple therapy. Methods : From July 2004 through October 2006, 52 patients for whom first‐line triple therapy (PPI, amoxicillin and clarithromycin) had failed were included in this study. They were treated with a quadruple regimen for 7 days (PPI, bismuth, tetracycline and metronidazole) as a second‐line therapy. For third‐line therapy, a rifabutin-based regimen (PPI, rifabutin and amoxicillin) was prescribed for 14 days. The H. pylori status was determined before and at least 4 weeks after therapy by the 13C urea breath test or by endoscopy with antral and corpus biopsies for a rapid urease test, histological examination and culture. Results : The mean age was 52.6 years. Thirteen patients (25%) of the 52 patients were dropped. The eradication rate of the quadruple therapy was 84.6% (33/39). Three patients of the 6 failures with quadruple therapy were then treated with the rifabutin-based regimen. The eradication rate of the rifabutin-based therapy was 100% (3/3). Adverse effects (10.2%) were reported in 4 patients who were treated with quadruple regimen. Conclusions : The quadruple regimen is still an effective second-line therapy for Korean patients who experience failure with PPI-based standard triple therapy. The rifabutin-based regimen could be used as a third-line rescue therapy in Korea. (Korean J Med 74:23-29, 2008) | - |
dc.format.extent | 7 | - |
dc.publisher | 대한내과학회 | - |
dc.title | 프로톤펌프억제제 포함 표준요법 실패 후 Helicobacter pylori 감염 구제요법 | - |
dc.title.alternative | Rescue therapies for Helicobacter pylori infection after failure of proton pump inhibitor-based standard triple therapy | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한내과학회지, v.74, no.1, pp 23 - 29 | - |
dc.identifier.kciid | ART001216557 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.title | 대한내과학회지 | - |
dc.citation.volume | 74 | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | Second line therapy | - |
dc.subject.keywordAuthor | Rescue therapy | - |
dc.subject.keywordAuthor | 이차 치료 | - |
dc.subject.keywordAuthor | 구제요법 | - |
dc.description.journalRegisteredClass | kci | - |
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