닭 배자에서 Bisphenol A가 척수의 세포고사에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박태양 | - |
dc.contributor.author | 차지영 | - |
dc.contributor.author | 최세경 | - |
dc.contributor.author | 조태일 | - |
dc.contributor.author | 김정연 | - |
dc.contributor.author | 김광준 | - |
dc.date.available | 2019-08-06T03:00:28Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 2508-4887 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/31193 | - |
dc.description.abstract | Objective : To investigate the effects of bisphenol A (BPA) on cell death pattern in neuronal development of chick embryos. Materials and Methods : We planned to compare the cytokinetic features in the normal chick embryo and those with BPA. Fifteen eggs were divided into three groups: the control group, BPA 50 µg/g egg group and BPA 200 µg/g egg group. Embryos were incubated for 56 hours (Hamburger & Hamilton stage 16) and then we injected BPA into embryos. The embryos were sectioned by 3 µm thickness at the level of wing buds and stained at 72 hours after incubation (HH stage 18). We observed cell death in the spinal cord using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) method. Results : The TUNEL-positivity markedly increased in proportion to the doses of BPA. The number of TUNEL-positive cells per section was 15.2±2.14 in the control group, 34.6±3.44 in the BPA 50µg/g egg group, 87.6±4.32 in the BPA 200 g/g egg group. Furthermore the contour of spinal cord was deformed as the doses of BPA raised. Conclusion : BPA causes neuronal cell death and exerts cytotoxic effect on early chick embryos. It suggests that BPA might have an effect on cytogenesis during neural tube development. | - |
dc.format.extent | 6 | - |
dc.publisher | 대한주산의학회 | - |
dc.title | 닭 배자에서 Bisphenol A가 척수의 세포고사에 미치는 영향 | - |
dc.title.alternative | The effect of bisphenol A on cell apoptosis pattern in the spinal cord of chick embryos | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Perinatology, v.19, no.3, pp 277 - 282 | - |
dc.identifier.kciid | ART001312031 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 282 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 277 | - |
dc.citation.title | Perinatology | - |
dc.citation.volume | 19 | - |
dc.subject.keywordAuthor | Chick embryo | - |
dc.subject.keywordAuthor | Bisphenol A | - |
dc.subject.keywordAuthor | Neural tube | - |
dc.subject.keywordAuthor | 닭배자 | - |
dc.subject.keywordAuthor | 신경관 | - |
dc.description.journalRegisteredClass | kciCandi | - |
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