대장 점막의 전암 병변과 암종에서 Nuclear Factor, p38 Mitogen-Activated Protein Kinase 및 Cyclin D1 단백 발현의 면역조직화학 분석
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Dae | - |
dc.contributor.author | Lee, Tae Jin | - |
dc.contributor.author | Park, Eon Sub | - |
dc.date.available | 2019-08-06T04:56:35Z | - |
dc.date.issued | 2008-12 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.issn | 2233-6869 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/31494 | - |
dc.description.abstract | Nuclear factor-&kgr;B p65 (NF-&kgr;B p65), nuclear factor-&kgr;B1 p50 (NF-&kgr;B p50) have been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. Recently, p38 mitogen-activated protein kinase (MAPK)/ NF-&kgr;B/ cyclin D1 signaling pathway has been shown to play an important part in the pathogenesis of human cancers. This study was designed to investigate the expression of NF-&kgr;B p65, NF-&kgr;B p50, p38 MAPK&agr;, and cyclin D1 proteins in premalignant lesions of colon and colorectal adenocarcinoma. Methods: Paraffin sections of 20 normal mucosa, 20 low-grade tubular adenoma, 20 high-grade tubular adenoma and 64 adenocarcinoma tissues were analysed immunohistochemically for the expression of NF-&kgr;B p65, NF-&kgr;B p50, p38 MAPK&agr;, and cyclin D1 proteins. Results: The expression of NF-&kgr;B p65, NF-&kgr;B p50, and p38 MAPK&agr; proteins were significantly higher in adenocarcinoma tissue in comparison with that in normal mucosa, low-grade tubular adenoma, and high-grade tubular adenoma tissues. Expression of NF-&kgr;B p50 was more frequent in poorly differentiated histologic grade, presence of nodal metastasis, and advanced stage. Expression of p38 MAPK&agr; protein was higher in advanced tumor stage, presence of nodal metastasis and advanced stage. Synchronous expression of NF-&kgr;B p65, NF-&kgr;B p50, p38 MAPK&agr;, and cyclin D1 proteins were significantly higher in adenocarcinoma tissue. Conclusions: With the increased expression of NF-&kgr;B p65, NF-&kgr;B p50, and p38 MAPK&agr; proteins, p38 MAPK/ NF-&kgr;B/ cyclin D1 signaling pathway may play a role in the pathogenesis of colorectal carcinoma. (Korean J Gastroenterol 2008;52:359-367) | - |
dc.format.extent | 9 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한소화기학회 | - |
dc.title | 대장 점막의 전암 병변과 암종에서 Nuclear Factor, p38 Mitogen-Activated Protein Kinase 및 Cyclin D1 단백 발현의 면역조직화학 분석 | - |
dc.title.alternative | Immunohistochemical Analysis of Nuclear Factor, p38, and Cyclin D1 Proteins in Premalignant Lesions and Carcinomas of the Colorectal Mucosa | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한소화기학회지, v.52, no.6, pp 359 - 367 | - |
dc.identifier.kciid | ART001298901 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-59149094412 | - |
dc.citation.endPage | 367 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 359 | - |
dc.citation.title | 대한소화기학회지 | - |
dc.citation.volume | 52 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Carcinoma | - |
dc.subject.keywordAuthor | Colorectal | - |
dc.subject.keywordAuthor | NF-κB p65 | - |
dc.subject.keywordAuthor | NF-κB p50 | - |
dc.subject.keywordAuthor | p38 MAPKα | - |
dc.subject.keywordAuthor | Cyclin D1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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