Aripirazole이 정신병적 증상을 동반한 파킨슨병 환자의 정신증상 및 운동증상에 미치는 효과

Abstract

Objectives：We compared the effect of aripiprazole, risperidone and quetiapine on the change of psychotic and motor symptoms during 4 weeks in Parkinson disease patients with psychotic feature after levodopa treatment. Methods：Our study included both inpatients and outpatients. Of sixty patients, nineteen patients took risperidone, 21 patients took quetiapine and 20 patients took aripiprazole. Before administration of antipsychotic medications and 4weeks later, we evaluated psychotic symptoms and motor symptoms with Scale for the Assessment of Positive Symptoms(SAPS), Scale for the Assessment of Negative Symptoms(SANS) and motor part of Unified Parkinson’s Disease Rating Scale(UPDRS). Results：After 4 weeks of antipsychotic treatments, the positive symptoms measured by SAPS showed group difference. In the post hoc test, risperidone group and aripiprazole group showed more improvement in positive symptoms scale than quetiapine. The change of motor symptoms measured by UPDRS showed group difference. In the post hoc test, the quetiapine group showed less aggravation in motor symptoms than the risperidone and the aripiprazole group. The aripiprazole group showed less aggravation in motor symptom than risperidone group, but there was no statistical significance. Conclusion：Comparing the effectiveness of three antipsychotics(risperidone, quetiapine and aripiprazole) on the motor and psychotic symptoms in Parkinsonian patients who developed psychotic symptoms after taking levodopa, aripiprazole showed greater improvement in positive symptoms than quetiapine and similar effect with risperidone.