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키누레닌 대사산물에 의한 신경세포 손상에 대한 Magnolol의 보호효과에 대한 연구

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dc.contributor.authorLee, Chang Uk-
dc.contributor.authorLee, Hyun Jung-
dc.contributor.authorKim, Do Hee-
dc.contributor.authorJang, Yeong Mi-
dc.contributor.authorLee, Sang Hyung-
dc.contributor.authorJeong, Yoonh Wa-
dc.contributor.authorKim, Dae Jin-
dc.contributor.authorChung, Yoon Hee-
dc.contributor.authorKim, Kyung Yong-
dc.contributor.authorKim, Sung Su-
dc.contributor.authorLee, Won Bok-
dc.date.available2019-08-09T01:02:05Z-
dc.date.issued2009-
dc.identifier.issn1225-9306-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32462-
dc.description.abstractThis study investigated the protective roles and mechanism of magnolol, from the stem bark of Magnolia officinalis against potential neurotoxin 3-hydroxykynurenine (3-HK)-induced neuronal cell death. For the evaluation of protective role of magnolol, we examined cell viability, apoptotic nuclei, change of mitochondrial membrane potential and caspase activity in human neuroblastoma SH-SY5Y cells. It was found that 3-HK induces neuronal cell death in the human neuroblastoma SH-SY5Y cell line. The reduced cell viability produced characteristic features such as cell shrinkages, plasma membrane blebbing, chromatin condensation, and nuclear fragmentation. The cells treated with 3-HK showed an increase in the concentration of reactive oxygen species (ROS) as well as in caspase activity. In addition, both are involved in the 3-HK-induced apoptosis. Magnolol attenuated the cell viability reduction by 3-HK in both a dose- and time-dependent manner. Optical microscopy showed that magnolol inhibited the cell morphological features in the 3-HK-treated cells. Furthermore, the increase in the ROS concentration and the caspase activities by 3-HK were also attenuated by magnolol. These results showed that magnolol has a protective effect on the 3-HK induced cell death by inhibiting ROS production and caspase activity.-
dc.format.extent6-
dc.publisher한국약용작물학회-
dc.title키누레닌 대사산물에 의한 신경세포 손상에 대한 Magnolol의 보호효과에 대한 연구-
dc.title.alternativeMagnolol Attenuates Neuronal Cell Death Induced by Kynurenine Metabolite-
dc.typeArticle-
dc.identifier.bibliographicCitation한국약용작물학회지, v.17, no.2, pp 145 - 150-
dc.identifier.kciidART001337028-
dc.description.isOpenAccessN-
dc.citation.endPage150-
dc.citation.number2-
dc.citation.startPage145-
dc.citation.title한국약용작물학회지-
dc.citation.volume17-
dc.publisher.location대한민국-
dc.subject.keywordAuthorMagnolol-
dc.subject.keywordAuthor3-hydroxykynureinine-
dc.subject.keywordAuthorMitochondria-
dc.subject.keywordAuthorROS-
dc.subject.keywordAuthorCaspase-3-
dc.description.journalRegisteredClasskci-
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