키누레닌 대사산물에 의한 신경세포 손상에 대한 Magnolol의 보호효과에 대한 연구
DC Field | Value | Language |
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dc.contributor.author | Lee, Chang Uk | - |
dc.contributor.author | Lee, Hyun Jung | - |
dc.contributor.author | Kim, Do Hee | - |
dc.contributor.author | Jang, Yeong Mi | - |
dc.contributor.author | Lee, Sang Hyung | - |
dc.contributor.author | Jeong, Yoonh Wa | - |
dc.contributor.author | Kim, Dae Jin | - |
dc.contributor.author | Chung, Yoon Hee | - |
dc.contributor.author | Kim, Kyung Yong | - |
dc.contributor.author | Kim, Sung Su | - |
dc.contributor.author | Lee, Won Bok | - |
dc.date.available | 2019-08-09T01:02:05Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1225-9306 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32462 | - |
dc.description.abstract | This study investigated the protective roles and mechanism of magnolol, from the stem bark of Magnolia officinalis against potential neurotoxin 3-hydroxykynurenine (3-HK)-induced neuronal cell death. For the evaluation of protective role of magnolol, we examined cell viability, apoptotic nuclei, change of mitochondrial membrane potential and caspase activity in human neuroblastoma SH-SY5Y cells. It was found that 3-HK induces neuronal cell death in the human neuroblastoma SH-SY5Y cell line. The reduced cell viability produced characteristic features such as cell shrinkages, plasma membrane blebbing, chromatin condensation, and nuclear fragmentation. The cells treated with 3-HK showed an increase in the concentration of reactive oxygen species (ROS) as well as in caspase activity. In addition, both are involved in the 3-HK-induced apoptosis. Magnolol attenuated the cell viability reduction by 3-HK in both a dose- and time-dependent manner. Optical microscopy showed that magnolol inhibited the cell morphological features in the 3-HK-treated cells. Furthermore, the increase in the ROS concentration and the caspase activities by 3-HK were also attenuated by magnolol. These results showed that magnolol has a protective effect on the 3-HK induced cell death by inhibiting ROS production and caspase activity. | - |
dc.format.extent | 6 | - |
dc.publisher | 한국약용작물학회 | - |
dc.title | 키누레닌 대사산물에 의한 신경세포 손상에 대한 Magnolol의 보호효과에 대한 연구 | - |
dc.title.alternative | Magnolol Attenuates Neuronal Cell Death Induced by Kynurenine Metabolite | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 한국약용작물학회지, v.17, no.2, pp 145 - 150 | - |
dc.identifier.kciid | ART001337028 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 150 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 145 | - |
dc.citation.title | 한국약용작물학회지 | - |
dc.citation.volume | 17 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Magnolol | - |
dc.subject.keywordAuthor | 3-hydroxykynureinine | - |
dc.subject.keywordAuthor | Mitochondria | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | Caspase-3 | - |
dc.description.journalRegisteredClass | kci | - |
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