Anomalous Dynamics of in Vivo Cargo Delivery by Motor Protein Multiplexes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Kyujin | - |
dc.contributor.author | Song, Sanggeun | - |
dc.contributor.author | Song, Yo Han | - |
dc.contributor.author | Hahn, Seungsoo | - |
dc.contributor.author | Kim, Ji-Hyun | - |
dc.contributor.author | Lee, Gibok | - |
dc.contributor.author | Jeong, In-Chun | - |
dc.contributor.author | Sung, Jaeyoung | - |
dc.contributor.author | Lee, Kang Taek | - |
dc.date.available | 2019-08-09T07:57:58Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 1948-7185 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32726 | - |
dc.description.abstract | Vesicle transport conducted by motor protein multiplexes (MPMs), which is ubiquitous among eukaryotes, shows anomalous and stochastic dynamics qualitatively different from the dynamics of thermal motion and artificial active matter; the relationship between in vivo vesicle-delivery dynamics and the underlying physicochemical processes is not yet quantitatively understood. Addressing this issue, we perform accurate tracking of individual vesicles, containing upconverting nanoparticles, transported by kinesin-dynein-multiplexes along axonal microtubules. The mean-square-displacement of vesicles along the microtubule exhibits unusual dynamic phase transitions that are seemingly inconsistent with the scaling behavior of the meanfirst-passage time over the travel length. These paradoxical results and the vesicle displacement distribution are quantitatively explained and predicted by a multimode MPM model, developed in the current work, where ATP-hydrolysis-coupled motion of MPM has both unidirectional and bidirectional modes. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Anomalous Dynamics of in Vivo Cargo Delivery by Motor Protein Multiplexes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jpclett.9b01106 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSICAL CHEMISTRY LETTERS, v.10, no.11, pp 3071 - 3079 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000471079400065 | - |
dc.identifier.scopusid | 2-s2.0-85066883907 | - |
dc.citation.endPage | 3079 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3071 | - |
dc.citation.title | JOURNAL OF PHYSICAL CHEMISTRY LETTERS | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | TUG-OF-WAR | - |
dc.subject.keywordPlus | SINGLE KINESIN MOLECULES | - |
dc.subject.keywordPlus | AXONAL-TRANSPORT | - |
dc.subject.keywordPlus | DIFFUSION | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | MICROTUBULE | - |
dc.subject.keywordPlus | TRACKING | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | MOVEMENT | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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