Prediction of future weight change with dopamine transporter in patients with Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | Pak, Kyoungjune | - |
dc.contributor.author | Kim, Heeyoung | - |
dc.contributor.author | Seok, Ju Won | - |
dc.contributor.author | Lee, Myung Jun | - |
dc.contributor.author | Shin, Seunghyeon | - |
dc.contributor.author | Kim, Keunyoung | - |
dc.contributor.author | Lee, Jae Meen | - |
dc.contributor.author | Seo, Youngduk | - |
dc.contributor.author | Kim, Bum Soo | - |
dc.contributor.author | Jun, Sungmin | - |
dc.contributor.author | Kim, In Joo | - |
dc.date.available | 2019-08-09T07:58:51Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 0300-9564 | - |
dc.identifier.issn | 1435-1463 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32751 | - |
dc.description.abstract | Fluctuating body weight is a commonly reported nonmotor feature in patients with Parkinson's disease (PD). We hypothesised that striatal dopamine transporter (DAT) density at the time of diagnosis might play an important role in weight regulation in patients with PD. DAT density was measured from I-123-FP-CIT single-photon emission computed tomography. Region-of-interest analyses were performed to measure the specific binding of I-123-FP-CIT to DAT, and the putamen-to-caudate nucleus ratio (PCR) was calculated. Body weight was measured at baseline (W0) and at 48months (W48). We classified subjects into three groups: weight loss, stable, and weight gain. In final analyses, 163 patients (106 men, 57 women) were included. PCR significantly differed by group in men, but not in women or across all patients. In men, PCR was slightly negatively associated with the percentage change in weight. No such correlation was found across all patients or in women. In univariate and multivariate logistic regression analyses, low PCR was associated with future weight gain in men with PD but not in women. In conclusion, striatal DAT availability at the time of diagnosis could predict subsequent weight change in men with PD. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER WIEN | - |
dc.title | Prediction of future weight change with dopamine transporter in patients with Parkinson's disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00702-019-02016-w | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURAL TRANSMISSION, v.126, no.6, pp 723 - 729 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000469230700003 | - |
dc.identifier.scopusid | 2-s2.0-85066048257 | - |
dc.citation.endPage | 729 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 723 | - |
dc.citation.title | JOURNAL OF NEURAL TRANSMISSION | - |
dc.citation.volume | 126 | - |
dc.type.docType | Article | - |
dc.publisher.location | 오스트리아 | - |
dc.subject.keywordAuthor | Parkinson's disease | - |
dc.subject.keywordAuthor | Dopamine plasma membrane transport proteins | - |
dc.subject.keywordAuthor | Neuroimaging | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | DIFFERENTIAL ROLES | - |
dc.subject.keywordPlus | NONMOTOR FEATURES | - |
dc.subject.keywordPlus | SEX-DIFFERENCES | - |
dc.subject.keywordPlus | STRIATUM | - |
dc.subject.keywordPlus | PUTAMEN | - |
dc.subject.keywordPlus | GAIN | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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