A nano-sized blending system comprising identical triblock copolymers with different hydrophobicity for fabrication of an anticancer drug nanovehicle with high stability and solubilizing capacity
DC Field | Value | Language |
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dc.contributor.author | Ngoc Ha Hoang | - |
dc.contributor.author | Sim, Taehoon | - |
dc.contributor.author | Lim, Chaemin | - |
dc.contributor.author | Thi Ngoc Le | - |
dc.contributor.author | Han, Sang Myung | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.date.available | 2019-08-09T08:01:14Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32813 | - |
dc.description.abstract | Background: A very common and simple method (known as the blending method) to formulate drug delivery systems with required properties is to physically mix amphiphilic block copolymers with different hydrophobicity. In addition to its simplicity, this blending strategy could help avoid the time and effort involved in the synthesis of block copolymers with the desired structure required for specific drug formulations. Purpose: We used the blending strategy to design a system that could overcome the problem of high hydrophobicity and be a good candidate for drug product development using PEG-PLA-PEG triblock copolymers. Methods: Two types of PEG-PLA-PEG triblock copolymers with similar (long) PLA molecular weights (MWs) and different PEG MWs were synthesized. The micellar formulations were prepared by blending the two block copolymers in various ratios. The size and stability of the blending systems were subsequently investigated to optimize the formulations for further studies. The loading properties of doxorubicin or paclitaxel into the optimized blending system were compared to that in mono systems (systems composed of only a single type of triblock copolymer). In vitro and in vivo anti-cancer effects of the preparations were evaluated to assess the use of the blending system as an optimal nanomedicine platform for insoluble anticancer agents. Results: The blending system (B20 system) with an optimized ratio of the triblock copolymers overcame the drawbacks of mono systems. Drug uptake from the drug-loaded B20 system and its anticancer effects against KB cells were superior compared to those of free drugs (doxorubicin hydrochloride and free paclitaxel). In particular, doxorubicin-loaded B20 resulted in extensive doxorubicin accumulation in tumor tissues and significantly higher in vivo anti-cancer effects compared to free doxorubicin. Conclusion: The blending system reported here could be a potential nanoplatform for drug delivery due to its simplicity and efficiency for pharmaceutical application. | - |
dc.format.extent | 16 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | A nano-sized blending system comprising identical triblock copolymers with different hydrophobicity for fabrication of an anticancer drug nanovehicle with high stability and solubilizing capacity | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S191126 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.14, pp 3629 - 3644 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000469106400001 | - |
dc.identifier.scopusid | 2-s2.0-85067580422 | - |
dc.citation.endPage | 3644 | - |
dc.citation.startPage | 3629 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 14 | - |
dc.type.docType | Article | - |
dc.publisher.location | 뉴질랜드 | - |
dc.subject.keywordAuthor | blending system | - |
dc.subject.keywordAuthor | block copolymer | - |
dc.subject.keywordAuthor | triblock copolymer | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | nanomedicine | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordPlus | POLY(ASPARTIC ACID-GRAFT-IMIDAZOLE)-BLOCK-POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | PEG-PLA-PEG | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | DELIVERY-SYSTEMS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOMEDICINE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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