Emerging PEGylated non-biologic drugs
- Authors
- Park, E.J.; Choi, J.; Lee, K.C.; Na, D.H.
- Issue Date
- Apr-2019
- Publisher
- Taylor and Francis Ltd
- Keywords
- aptamers; non-biologic drugs; PEGylation; small organic molecules; synthetic peptides
- Citation
- Expert Opinion on Emerging Drugs, v.24, no.2, pp 107 - 119
- Pages
- 13
- Journal Title
- Expert Opinion on Emerging Drugs
- Volume
- 24
- Number
- 2
- Start Page
- 107
- End Page
- 119
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/33101
- DOI
- 10.1080/14728214.2019.1604684
- ISSN
- 1472-8214
1744-7623
- Abstract
- Introduction: PEGylation is a well-established technology for improving the therapeutic value of drugs by attaching polyethylene glycol (PEG). The first PEGylated enzyme products appeared on the market in the early 1990s; currently, more than 18 PEGylated products have been approved by Food and Drug Administration, which encompass various classes of drug molecules, such as enzymes, interferons, granulocyte colony-stimulating factors, hormones, antibody fragments, coagulation factors, oligonucleotide aptamers, synthetic peptides, and small organic molecules. Areas covered: While PEGylated products mainly comprise biologic drugs, such as recombinant proteins and enzymes, non-biologic drugs have recently emerged as a target for PEGylation. This review focuses on the recent development of PEGylated non-biologic drugs, such as small organic molecules, synthetic peptides, and aptamers. Expert opinion: Several PEGylated versions of anti-cancer drugs, opioid agonists, glucagon-like peptide-1 receptor agonists, and oligonucleotide aptamers are in active development stage, and it is likely that they will have a dramatic impact on the market. Although some safety concerns about PEG in clinical trials have been recently issued, PEGylation is still a commercially attractive proposition as a half-life extension technology for long-acting drug development. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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