Effectiveness of platelet function analyzer-100 for laboratory detection of anti-platelet drug-induced platelet dysfunction
DC Field | Value | Language |
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dc.contributor.author | Kweon, Oh Joo | - |
dc.contributor.author | Lim, Yong Kwan | - |
dc.contributor.author | Kim, Bohyun | - |
dc.contributor.author | Lee, Mi-Kyung | - |
dc.contributor.author | Kim, Hye Ryoun | - |
dc.date.available | 2019-03-08T06:57:01Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.issn | 2234-3814 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3314 | - |
dc.description.abstract | Background: High on-treatment platelet reactivity (HTPR) is the phenomenon wherein patients exhibit normal platelet activity in laboratory testing despite adequate adherence to anti-platelet treatment. We investigated the detection rates of Platelet Function Analyzer (PFA)-100 (Dade Behring AG, Düdingen, Switzerland) for drug-induced platelet dysfunction and analyzed potential contributors to HTPR with practical PFA-100 data over six years. Methods: We used data from 6,957 patients who underwent PFA-100 testing after receiving aspirin, clopidogrel, or non-steroidal anti-inflammatory drugs (NSAIDs). Of these, 6,163 patients were tested with only the collagen/epinephrine cartridge (Col/EPI) of PFA-100; 794 were tested with both Col/EPI and the collagen/ADP cartridge (Col/ADP). We calculated PFA-100 closure time (CT) for each drug and compared the clinical and laboratory characteristics of the patients with prolonged CTs and normal CTs (i.e., HTPR). Results: In Col/EPI, 73.2% (365/499), 72.6% (390/537), and 55.3% (3,442/6,228) patients showed prolonged CTs for aspirin, clopidogrel, and NSAIDs, respectively. In Col/ADP, prolonged CTs were observed in 37.4% (34/91), 43.2% (35/81), and 29.6% (200/676) of patients receiving aspirin, clopidogrel, and NSAIDs, respectively. Of the patients tested with both cartridges, 88.9% (48/54), 95.3% (41/43), and 89.0% (577/648) of the patients receiving aspirin, clopidogrel, and NSAIDs had prolonged CTs, and 10.0% (79/794) showed normal CTs regardless of drugs. For clopidogrel users (both cartridges), there were more patients with malignancies in the normal CT than prolonged CT group. Conclusions: PFA-100 is not sufficiently effective for laboratory screening of drug-induced platelet dysfunction. Malignancy may contribute to clopidogrel-related HTPR in PFA-100. © 2018 Seoul National University Institute for Cognitive Science. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Seoul National University, Institute for Cognitive Science | - |
dc.title | Effectiveness of platelet function analyzer-100 for laboratory detection of anti-platelet drug-induced platelet dysfunction | - |
dc.type | Article | - |
dc.identifier.doi | 10.3343/alm.2019.39.1.23 | - |
dc.identifier.bibliographicCitation | Annals of Laboratory Medicine, v.39, no.1, pp 23 - 30 | - |
dc.identifier.kciid | ART002430456 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000449506500004 | - |
dc.identifier.scopusid | 2-s2.0-85055821304 | - |
dc.citation.endPage | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.title | Annals of Laboratory Medicine | - |
dc.citation.volume | 39 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Platelet Function Analyzer-100 | - |
dc.subject.keywordAuthor | Aspirin | - |
dc.subject.keywordAuthor | Clopidogrel | - |
dc.subject.keywordAuthor | Non-steroidal anti-inflammatory drugs | - |
dc.subject.keywordAuthor | High on-treatment platelet reactivity | - |
dc.subject.keywordPlus | ARTERY-DISEASE PATIENTS | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | FUNCTION TESTS | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | COAGULATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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