극 저주파 전자기장이 N-bis(2-hydroxypropyl)nitrosamine과 Sulfadimethoxine에 의해 유발된 갑상샘 암에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수환 | - |
dc.contributor.author | 박용진 | - |
dc.contributor.author | 박언섭 | - |
dc.contributor.author | 김용석 | - |
dc.contributor.author | 최유신 | - |
dc.contributor.author | 김범규 | - |
dc.contributor.author | 박성준 | - |
dc.contributor.author | 정세민 | - |
dc.date.available | 2019-08-13T06:02:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.issn | 2288--679 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/33225 | - |
dc.description.abstract | Purpose: Long-term exposure to extremely low-frequency (60 Hz) electromagnetic fields (ELF-EMF) raises the questions of the induction of biological effects including tumorigenesis. One mechanism through which ELF-MFS could influence neoplastic development is the imbalance of cellular proliferation and cell apoptosis. The present study investigated the effect of ELF-EMF on chemically-induced thyroid carcinogenesis in a rat. Methods: We examined cellular proliferation index measured by anti-Ki-67 antigen, apoptosis, apoptosis related proteins such as caspase 3 and p53, and cell cycle-related proteins (cyclin D1 and p21WAF1/Cip1). Forty Male F344 rats received a subcutaneous N-bis(2-hydroxypropyl)nitrosamine (DHPN, 2,800 mg/kg) injection, and 1 week later were allowed free access to drinking water containing sulfadimethoxine (0.1%) for 12 weeks. Twenty rats were exposed by ELF-EMF. During the carcinogenesis, sequential histological changes from hyperplasia, adenoma, and ultimately to overt carcinomas were noted. Results: The exposure group of ELF-EMF, significantly increases the number size of carcinomas. Also, the proliferative and apoptotic indices were significantly increased in the ELF-EMF exposure group than in the control group. The caspase 3 protein expression did not show any significant changes between ELF-EMF group and control group. The p53 protein was not detected in both ELF-EMF exposure and control group. Among the cell cycle related proteins, cyclin D1, not p21WAF1/Cip1, was significantly increased in adenomas and carcinomas in ELF-EMF exposure group compared with the control group. Conclusion: Exposure of ELF-EMF effects on chemically-induced rat thyroid carcinogenesis as results of altered increase of cellular proliferation, apoptosis, and cyclin D1 expression. | - |
dc.format.extent | 9 | - |
dc.publisher | 대한외과학회 | - |
dc.title | 극 저주파 전자기장이 N-bis(2-hydroxypropyl)nitrosamine과 Sulfadimethoxine에 의해 유발된 갑상샘 암에 미치는 영향 | - |
dc.title.alternative | Effects of Extremely Low Frequency Elecromagnetic Fields on Thyroid Carcinogenesis Induced by N-bis(2-hydroxypropyl)nitrosamine and Sulfadimethoxine | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한외과학회지, v.77, no.3, pp 161 - 169 | - |
dc.identifier.kciid | ART001369604 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 169 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.title | 대한외과학회지 | - |
dc.citation.volume | 77 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Extremely low frequency magnetic field | - |
dc.subject.keywordAuthor | Thyroid carcinogenesis | - |
dc.subject.keywordAuthor | N-bis(2-hydroxypropyl)nitrosamine (DHPN) | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Cell cycle-related proteins | - |
dc.subject.keywordAuthor | 극 저주파 전자기장 | - |
dc.subject.keywordAuthor | 갑상샘 발암 | - |
dc.subject.keywordAuthor | 세포자멸사 | - |
dc.subject.keywordAuthor | 세포주기관련 단백 | - |
dc.description.journalRegisteredClass | kci | - |
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