Influence of liver fibrosis on prognosis after surgical resection for resectable single hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Suh, Suk-Won | - |
dc.contributor.author | Choi, Yoo Shin | - |
dc.date.available | 2019-03-08T06:57:22Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1445-1433 | - |
dc.identifier.issn | 1445-2197 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3346 | - |
dc.description.abstract | Background: Surgical resection (SR) is recommended for single hepatocellular carcinoma (HCC) in patients with well-preserved liver function. However, unexpected liver fibrosis sometimes found at the SR which leads to a poor outcome. This study investigated the influence of liver fibrosis on prognosis after SR for HCC. Methods: A total of 189 patients with Child-Turcotte-Pugh grade A who underwent curative SR for a single HCC <5 cm were evaluated. Patients were assigned to two groups based on the degree of fibrosis (mild or severe), as determined by histological evaluation. Results: Severe fibrosis was present in 49 patients (25.9%); these patients had greater posthepatectomy liver failure (P = 0.000) and HCC recurrence (P = 0.016). Severe liver fibrosis (hazard ratio (HR) = 1.849, 95% confidence interval (CI) 1.191–2.869; P = 0.006), microvascular invasion (HR = 1.854, 95% CI 1.183–2.906; P = 0.007), and poor histologic grade (HR = 2.097, 95% CI 1.230–3.574; P = 0.007) were related to HCC recurrence. Conclusion: Severe fibrosis can be found even in patients with well-preserved liver function and it leads to poorer early post-operative and late oncologic outcomes, therefore it should be considered before therapeutic decision making of HCC. © 2018 Royal Australasian College of Surgeons | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing | - |
dc.title | Influence of liver fibrosis on prognosis after surgical resection for resectable single hepatocellular carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/ans.14732 | - |
dc.identifier.bibliographicCitation | ANZ Journal of Surgery, v.89, no.3, pp 211 - 215 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000460302200034 | - |
dc.identifier.scopusid | 2-s2.0-85052617067 | - |
dc.citation.endPage | 215 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 211 | - |
dc.citation.title | ANZ Journal of Surgery | - |
dc.citation.volume | 89 | - |
dc.type.docType | Article in Press | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Child-Turcotte-Pugh grade A | - |
dc.subject.keywordAuthor | liver fibrosis | - |
dc.subject.keywordAuthor | single hepatocellular carcinoma | - |
dc.subject.keywordAuthor | surgical resection | - |
dc.subject.keywordPlus | PORTAL-HYPERTENSION | - |
dc.subject.keywordPlus | CHRONIC HEPATITIS | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | SURGERY | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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