XAV939, a Wnt/β-catenin pathway modulator, has inhibitory effects on LPS-induced inflammatory response
DC Field | Value | Language |
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dc.contributor.author | Jang, Jaewoong | - |
dc.contributor.author | Jung, Yoonju | - |
dc.contributor.author | Chae, Seyeon | - |
dc.contributor.author | Bae, Taehyun | - |
dc.contributor.author | Kim, Seok-Min | - |
dc.contributor.author | Shim, Yae Jie | - |
dc.contributor.author | Chung, Sang-In | - |
dc.contributor.author | Yoon, Yoosik | - |
dc.date.available | 2019-03-08T06:57:27Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 0892-3973 | - |
dc.identifier.issn | 1532-2513 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3355 | - |
dc.description.abstract | Aim: In this study, we report the anti-inflammatory activity of XAV939, a modulator of the Wnt/β-catenin pathway. Methods: WNT/β-catenin pathway and NF-κB signaling pathway were examined in LPS-stimulated human bronchial epithelial cells and effects of XAV939 on these pathways were analyzed. The effect of XAV939 was confirmed in human umbilical vein endothelial cells. Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-α, IL-1β, MCP-1, MMP-9, iNOS and COX-2 were significantly and dose-dependently suppressed by XAV939. LPS-induced NF-κB signaling, such as IκB phosphorylation and degradation as well as nuclear translocation of NF-κB, was also suppressed by XAV939. Target DNA binding of NF-κB was significantly and dose-dependently suppressed by XAV939 during LPS-induced inflammatory response. The suppressive effects of XAV939 on NF-κB signaling, target DNA binding of NF-κB and pro-inflammatory gene expression were all rescued by over expression of β-catenin, which shows that the anti-inflammatory effect of XAV939 is mediated by the modulation of β-catenin, a central component of the WNT/β-catenin pathway. Conclusion: The findings of this study showed that XAV939 exerts anti-inflammatory effects through the modulation of the Wnt/β-catenin pathway. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Taylor and Francis Ltd | - |
dc.title | XAV939, a Wnt/β-catenin pathway modulator, has inhibitory effects on LPS-induced inflammatory response | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/08923973.2018.1536984 | - |
dc.identifier.bibliographicCitation | Immunopharmacology and Immunotoxicology, v.41, no.3, pp 394 - 402 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000473448900005 | - |
dc.identifier.scopusid | 2-s2.0-85057520715 | - |
dc.citation.endPage | 402 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 394 | - |
dc.citation.title | Immunopharmacology and Immunotoxicology | - |
dc.citation.volume | 41 | - |
dc.type.docType | Article in Press | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | Wnt/β-catenin pathway | - |
dc.subject.keywordAuthor | XAV939 | - |
dc.subject.keywordPlus | SMALL-MOLECULE INHIBITORS | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | TANKYRASE 1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | AXIN | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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