Development of S-methylmethionine sulfonium derivatives and their skin-protective effect against ultraviolet exposure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, W.-S. | - |
dc.contributor.author | Kim, W.-K. | - |
dc.contributor.author | Choi, N. | - |
dc.contributor.author | Suh, W. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kim, D.-D. | - |
dc.contributor.author | Kim, I. | - |
dc.contributor.author | Sung, J.-H. | - |
dc.date.available | 2019-03-08T06:57:39Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.issn | 2005-4483 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3376 | - |
dc.description.abstract | In a previous study, we have demonstrated that S-methylmethionine sulfonium (SMMS) confers wound-healing and photoprotective effects on the skin, suggesting that SMMS can be used as a cosmetic raw material. However, it has an unpleasant odor. Therefore, in the present study, we synthesized odor-free SMMS derivatives by eliminating dimethyl sulfide, which is the cause of the unpleasant odor and identified two derivatives that exhibited skin-protective effects: one derivative comprised (2S,4S)- and (2R,4S)-2-phenylthiazolidine-4-carboxylic acid and the other comprised (2S,4R)-, (2S,4S)-, (2R,4R)-, and (2R,4S)-2-phenyl-1,3-thiazinane-4-carboxylic acid. We performed in vitro proliferation assays using human dermal fibroblasts (hDFs) and an immortalized human keratinocyte cell line (HaCaT). The two SMMS derivatives were shown to increase hDF and HaCaT cell proliferation as well as improve their survival by protecting against ultraviolet exposure. Moreover, the derivatives regulated the expression of collagen type I and MMP mRNAs against ultraviolet exposure in hDFs, suggesting that these derivatives can be developed as cosmetic raw materials. © 2018 The Korean Society of Applied Pharmacology. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Applied Pharmacology | - |
dc.title | Development of S-methylmethionine sulfonium derivatives and their skin-protective effect against ultraviolet exposure | - |
dc.type | Article | - |
dc.identifier.doi | 10.4062/biomolther.2017.109 | - |
dc.identifier.bibliographicCitation | Biomolecules and Therapeutics, v.26, no.3, pp 306 - 312 | - |
dc.identifier.kciid | ART002343097 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000431656900009 | - |
dc.identifier.scopusid | 2-s2.0-85046721987 | - |
dc.citation.endPage | 312 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 306 | - |
dc.citation.title | Biomolecules and Therapeutics | - |
dc.citation.volume | 26 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | S-methylmethionine derivatives | - |
dc.subject.keywordAuthor | UVA/B protection | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.