LC-MS/MS characterization, anti-inflammatory effects and antioxidant activities of polyphenols from different tissues of Korean Petasites japonicus (Meowi)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jin Young | - |
dc.contributor.author | Desta, Kebede Taye | - |
dc.contributor.author | Saralamma, Venu Venkatarame Gowda | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.contributor.author | Lee, Soo Jung | - |
dc.contributor.author | Kim, Seong Min | - |
dc.contributor.author | Paramanantham, Anjugam | - |
dc.contributor.author | Lee, Ho Jeong | - |
dc.contributor.author | Kim, Yun-Hi | - |
dc.contributor.author | Shin, Ho-Chul | - |
dc.contributor.author | Shim, Jae-Han | - |
dc.contributor.author | Warda, Mohamad | - |
dc.contributor.author | Hacimuftuoglu, Ahmet | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Shin, Sung Chul | - |
dc.contributor.author | Kim, Gon-Sup | - |
dc.contributor.author | Abd El-Aty, A. M. | - |
dc.date.available | 2019-03-08T07:36:19Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0269-3879 | - |
dc.identifier.issn | 1099-0801 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3532 | - |
dc.description.abstract | The Korean Petasites japonicus is a perennial plant used in folk medicine as a remedy for many diseases and popularly consumed as spring greens. Ten polyphenols were characterized from the leaves, stems and roots of this plant via high-performance liquid chromatography-tandem mass spectrometry. Individual polyphenols were quantified for the first time using calibration curves of six structurally related external standards. Validation data indicated that coefficients of determinations (R-2) were 0.9702 for all standards. Recoveries measured at 50 and 100mg/L were 80.0-91.9 and 80.3-105.3%, respectively. Precisions at these two concentration levels were 0.7-6.1 and 1.1-5.5%, respectively. The total number of identified components was largest for the leaves and smallest for the stems. The leaf and root polyphenolic extracts showed anti-inflammatory effects by inducing LPS-activated COX-2 and iNOS protein levels in mouse macrophage RAW 264.7 cells. The antioxidant capacity of the polyphenols, when evaluated for DPPH (,-diphenyl--picrylhydrazyl)(?), ABTS(+) [2-2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] and superoxide radical scavenging activities, and in ferric reducing ability of plasma (FRAP) assays, was highest in the leaf and lowest in the stem. This trend suggests that the antioxidant capacities depend primarily on polyphenol concentration in each tissue. The current findings suggest that polyphenols derived from P. japonicas tissues could have potential as functional health foods. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | LC-MS/MS characterization, anti-inflammatory effects and antioxidant activities of polyphenols from different tissues of Korean Petasites japonicus (Meowi) | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bmc.4033 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL CHROMATOGRAPHY, v.31, no.12 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000415361700024 | - |
dc.identifier.scopusid | 2-s2.0-85022190747 | - |
dc.citation.number | 12 | - |
dc.citation.title | BIOMEDICAL CHROMATOGRAPHY | - |
dc.citation.volume | 31 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | antioxidants | - |
dc.subject.keywordAuthor | high performance liquid chromatography | - |
dc.subject.keywordAuthor | Petasites japonicus | - |
dc.subject.keywordAuthor | polyphenols | - |
dc.subject.keywordAuthor | tandem mass spectrometry | - |
dc.subject.keywordPlus | TANDEM MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | FLAVONOID GLYCOSIDES | - |
dc.subject.keywordPlus | MSN IDENTIFICATION | - |
dc.subject.keywordPlus | PHENOLIC-COMPOUNDS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | KAINIC ACID | - |
dc.subject.keywordPlus | ESI-MS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.