흰민들레(Taraxacum coreanum) 활성획분인 Ethylacetate Fraction의 Peroxynitrite에 대한 산화적 스트레스 개선 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최지명 | - |
dc.contributor.author | 최미진 | - |
dc.contributor.author | 이설림 | - |
dc.contributor.author | 야마베노리꼬 | - |
dc.contributor.author | 이상현 | - |
dc.contributor.author | 조은주 | - |
dc.date.available | 2019-08-23T01:06:58Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.issn | 2288-3657 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/35366 | - |
dc.description.abstract | The EtOAc fraction from Taraxacum coreanum showed the strongest radical scavenging activity. The protective activity of active EtOAc fraction against the oxidative stress was investigated under cellular system using LLC-PK1 renal epithelial cell. The LLC-PK1 cells showed loss of the cell viability and elevation for lipid peroxidation by the treatment with generator of peroxynitrite (ONOO-), 3-mor- -pholinosydnonimine, and its precursors, nitric oxide (NO) and superoxide anion (O2 ), produced by sodium nitroprusside and pyrogallol, respectively. However, the treatment of the EtOAc fraction significantly, dose-dependently, recovered cell viability and inhibited lipid peroxidation against both ONOO- itself, and its precursors of NO and O2 . At 100μg/ml of the EtOAC fraction, the cell viability was significantly increased to 93.4% from 61.0%, and lipid peroxidation was inhibited to 0.104 nmol/mg protein from 0.494 nmol/mg protein. The present study suggests that T. coreanum would have the protective potential from ONOO--induced oxidative stress. | - |
dc.format.extent | 6 | - |
dc.publisher | 대한암예방학회 | - |
dc.title | 흰민들레(Taraxacum coreanum) 활성획분인 Ethylacetate Fraction의 Peroxynitrite에 대한 산화적 스트레스 개선 효과 | - |
dc.title.alternative | Protective Effects of Ethylacetate Fraction from Taraxacum coreanum against Peroxynitrite-induced Oxidative Damage under Cellular System | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한암예방학회지, v.17, no.3, pp 251 - 256 | - |
dc.identifier.kciid | ART001711679 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 256 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 251 | - |
dc.citation.title | 대한암예방학회지 | - |
dc.citation.volume | 17 | - |
dc.subject.keywordAuthor | Taraxacum coreanum | - |
dc.subject.keywordAuthor | LLC-PK1 | - |
dc.subject.keywordAuthor | Peroxynitrite | - |
dc.subject.keywordAuthor | Superoxide anion | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.description.journalRegisteredClass | kci | - |
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