Polymer-directed Crystallization of Sibutramine using Cellulose Derivatives
- Authors
- Bae, Harim; Lee, Hyeseung; Lee, Minkyung; Lee, Jonghwi
- Issue Date
- 2011
- Publisher
- 한국약제학회
- Keywords
- Sibutramine; Crystallization; Polymer-directed crystallization; Polymer drug interaction; Crystal habit
- Citation
- Journal of Pharmaceutical Investigation, v.41, no.1, pp 45 - 50
- Pages
- 6
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 41
- Number
- 1
- Start Page
- 45
- End Page
- 50
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/35783
- DOI
- 10.4333/KPS.2011.41.1.045
- ISSN
- 2093-5552
2093-6214
- Abstract
- Nonclassical pathway of crystallization has been utilized to modify the properties and morphologies of inorganic and organic/inorganic materials. In here, the polymer-directed crystallization method has been applied to the pharmaceutical active ingredient to assess the applicability for as a particle engineering tool. The polymer-directed crystallization was successful to modifying the crystal size, habit and morphology, but it was not effective to discover the novel polymorphs of Sibutramine (SB). SB was selected as a model drug and polyacrylic acid (PAA), polyethylene imine (PEI) and chitosan (CHI) were added as a crystallization pathway modifier. SB was crystallized via drowning crystallization using methanol or ethanol as a solvent and water as a non-solvent. The significant interactions between polymer and the drug were confirmed by measuring the solubility of the drug in presence of polymer during the crystallization. The crystal forms of SB are characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and optical microscope (OM). The polymer-directed crystallization seems to be able to modify the crystal properties of pharmaceutical active ingredient, which is critical in determining the bioavailability, processability, and stability.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.