Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Chang-Ro | - |
dc.contributor.author | Lee, Jung Hun | - |
dc.contributor.author | Park, Kwang Seung | - |
dc.contributor.author | Jeon, Jeong Ho | - |
dc.contributor.author | Kim, Young Bae | - |
dc.contributor.author | Cha, Chang-Jun | - |
dc.contributor.author | Jeong, Byeong Chul | - |
dc.contributor.author | Lee, Sang Hee | - |
dc.date.available | 2019-03-08T07:37:19Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 2235-2988 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3636 | - |
dc.description.abstract | Klebsiella pneumoniae is one of the most clinically relevant species in immunocompromised individuals responsible for community-acquired and nosocomial infections, including pneumonias, urinary tract infections, bacteremias, and liver abscesses. Since the mid-1980s, hypervirulent K. pneumoniae, generally associated with the hypermucoviscosity phenotype, has emerged as a clinically significant pathogen responsible for serious disseminated infections, such as pyogenic liver abscesses, osteomyelitis, and endophthalmitis, in a generally younger and healthier population. Hypervirulent K. pneumoniae infections were primarily found in East Asia and now are increasingly being reported worldwide. Although most hypervirulent K. pneumoniae isolates are antibiotic-susceptible, some isolates with combined virulence and resistance, such as the carbapenem-resistant hypervirulent K. pneumoniae isolates, are increasingly being detected. The combination of multidrug resistance and enhanced virulence has the potential to cause the next clinical crisis. To better understand the basic biology of hypervirulent K. pneumoniae, this review will provide a summarization and discussion focused on epidemiology, hypervirulence-associated factors, and antibiotic resistance mechanisms of such hypervirulent strains. Epidemiological analysis of recent clinical isolates in China warns the global dissemination of hypervirulent K. pneumoniae strains with extensive antibiotic resistance in the near future. Therefore, an immediate response to recognize the global dissemination of this hypervirulent strain with resistance determinants is an urgent priority. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fcimb.2017.00483 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v.7, no.NOV | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000415825600001 | - |
dc.identifier.scopusid | 2-s2.0-85034811992 | - |
dc.citation.number | NOV | - |
dc.citation.title | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
dc.citation.volume | 7 | - |
dc.type.docType | Review | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | antimicrobial resistance | - |
dc.subject.keywordAuthor | hypervirulent Klebsiella pneumoniae | - |
dc.subject.keywordAuthor | epidemiology | - |
dc.subject.keywordAuthor | resistance mechanism | - |
dc.subject.keywordAuthor | serotype | - |
dc.subject.keywordAuthor | sequence type | - |
dc.subject.keywordPlus | PYOGENIC LIVER-ABSCESS | - |
dc.subject.keywordPlus | CAPSULAR POLYSACCHARIDE SYNTHESIS | - |
dc.subject.keywordPlus | VENTILATOR-ASSOCIATED PNEUMONIA | - |
dc.subject.keywordPlus | SEROTYPE K1 | - |
dc.subject.keywordPlus | MOLECULAR CHARACTERISTICS | - |
dc.subject.keywordPlus | COLISTIN RESISTANCE | - |
dc.subject.keywordPlus | HYPERMUCOVISCOSITY PHENOTYPE | - |
dc.subject.keywordPlus | ACINETOBACTER-BAUMANNII | - |
dc.subject.keywordPlus | MAINLAND CHINA | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.