Glutathione peroxidase-1 gene rescues cocaine-induced conditioned place preference in mice by inhibiting σ-1 receptor expression
DC Field | Value | Language |
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dc.contributor.author | Pham, D.T. | - |
dc.contributor.author | Chung, Y.H. | - |
dc.contributor.author | Mai, H.N. | - |
dc.contributor.author | Sharma, N. | - |
dc.contributor.author | Yun, J. | - |
dc.contributor.author | Kim, H.J. | - |
dc.contributor.author | Cheong, J.H. | - |
dc.contributor.author | Jeong, J.H. | - |
dc.contributor.author | Kim, D.-J. | - |
dc.contributor.author | Shin, E.-J. | - |
dc.contributor.author | Kim, H.-C. | - |
dc.date.available | 2019-08-30T03:00:22Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0305-1870 | - |
dc.identifier.issn | 1440-1681 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36467 | - |
dc.description.abstract | The aim of this study was to investigate whether the glutathione peroxidase-1 gene (GPx-1) affects cocaine-induced conditioned place preference (CPP) using a mouse model. Cocaine-induced CPP was accompanied by an increase in the level of σ-1 receptor in the nucleus accumbens (NAc). This phenomenon was more pronounced in the GPx-1 gene knockout (GPx-1 KO) than in wild type (WT) mice. In contrast, the CPP and expression of σ-1 receptor were much less pronounced in GPx-1-overexpressing transgenic (GPx-1 TG) mice than non-transgenic (non-TG) mice. Treatment of the mice with BD1047, a σ-1 receptor antagonist, significantly attenuated both cocaine-induced CPP and c-Fos-immunoreactivity (c-Fos-IR) in WT and GPx-1 KO mice, although the effects were more evident in the latter group. Despite the protective effects of BD1047 on cocaine-induced CPP and c-Fos in non-TG mice, there were no additional protective effects in cocaine-treated GPx-1 TG mice, indicating that the σ-1 receptor is a critical target for GPx-1-mediated psychoprotective activity. Overall, our results suggest that GPx-1 attenuates cocaine-induced CPP via inhibition of σ-1 receptor expression. © 2019 John Wiley & Sons Australia, Ltd | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing | - |
dc.title | Glutathione peroxidase-1 gene rescues cocaine-induced conditioned place preference in mice by inhibiting σ-1 receptor expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/1440-1681.13140 | - |
dc.identifier.bibliographicCitation | Clinical and Experimental Pharmacology and Physiology, v.46, no.9, pp 791 - 797 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000480549200001 | - |
dc.identifier.scopusid | 2-s2.0-85070481935 | - |
dc.citation.endPage | 797 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 791 | - |
dc.citation.title | Clinical and Experimental Pharmacology and Physiology | - |
dc.citation.volume | 46 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | cocaine | - |
dc.subject.keywordAuthor | conditioned place preference | - |
dc.subject.keywordAuthor | glutathione peroxidase-1 gene | - |
dc.subject.keywordAuthor | σ-1 receptor | - |
dc.subject.keywordPlus | BEHAVIORAL SENSITIZATION | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | DEXTROMETHORPHAN | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | ADDICTION | - |
dc.subject.keywordPlus | DEFICIENT | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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