Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan with improved dissolution and bioavailability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeom, Dong Woo | - |
dc.contributor.author | Chae, Bo Ram | - |
dc.contributor.author | Kim, Jin Han | - |
dc.contributor.author | Chae, Jun Soo | - |
dc.contributor.author | Shin, Dong Jun | - |
dc.contributor.author | Kim, Chang Hyun | - |
dc.contributor.author | Kim, Sung Rae | - |
dc.contributor.author | Choi, Ji Ho | - |
dc.contributor.author | Song, Seh Hyon | - |
dc.contributor.author | Oh, Dongho | - |
dc.contributor.author | Sohn, Se Il | - |
dc.contributor.author | Choi, Young Wook | - |
dc.date.available | 2019-03-08T07:37:25Z | - |
dc.date.issued | 2017-11-07 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3646 | - |
dc.description.abstract | In order to improve the dissolution and oral bioavailability of valsartan (VST), and reduce the required volume for treatment, we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) composed of VST (80 mg), Capmul (R) MCM (13.2 mg), Tween (R) 80 (59.2 mg), Transcutol (R) P (59.2 mg), and Poloxamer 407 (13.2 mg). In the present study, by using Florite (R) PS-10 (119.1 mg) and Vivapur (R) 105 (105.6 mg) as solid carriers, VST-loaded solidified SuSMEDDS (S-SuSMEDDS) granules were successfully developed, which possessed good flow properties and rapid drug dissolution. By introducing croscarmellose sodium (31 mg) as a superdisintegrant, S-SuSMEDDS tablets were also successfully formulated, which showed fast disintegration and high dissolution efficiency. Preparation of granules and tablets was successfully optimized using D-optimal mixture design and 3-level factorial design, respectively, resulting in percentage prediction errors of < 10%. In pharmacokinetic studies in rats, the relative bioavailability of the optimized granules was 107% and 222% of values obtained for SuSMEDDS and Diovan (R) powder, respectively. Therefore, we conclude that novel S-SuSMEDDS formulations offer great potential for developing solid dosage forms of a liquefied formulation such as SuSMEDDS, while improving oral absorption of drugs with poor water solubility. | - |
dc.format.extent | 20 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan with improved dissolution and bioavailability | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.21691 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.55, pp 94297 - 94316 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000414608400090 | - |
dc.identifier.scopusid | 2-s2.0-85032926479 | - |
dc.citation.endPage | 94316 | - |
dc.citation.number | 55 | - |
dc.citation.startPage | 94297 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | valsartan | - |
dc.subject.keywordAuthor | SMEDDS | - |
dc.subject.keywordAuthor | solid carrier | - |
dc.subject.keywordAuthor | tablet | - |
dc.subject.keywordAuthor | optimization | - |
dc.subject.keywordPlus | DISINTEGRATING TABLETS | - |
dc.subject.keywordPlus | ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | COMPACTION BEHAVIOR | - |
dc.subject.keywordPlus | PARTICLE-SIZE | - |
dc.subject.keywordPlus | S-SMEDDS | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | DISPERSION | - |
dc.subject.keywordPlus | IBUPROFEN | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | GRANULE | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.