Effects of two-dimensional materials on human mesenchymal stem cell behaviors
DC Field | Value | Language |
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dc.contributor.author | Suhito, Intan Rosalina | - |
dc.contributor.author | Han, Yoojoong | - |
dc.contributor.author | Kim, Da-Seul | - |
dc.contributor.author | Son, Hyungbin | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.date.available | 2019-03-08T07:37:26Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3649 | - |
dc.description.abstract | Graphene, a typical two-dimensional (2D) material, is known to affect a variety of stem cell behaviors including adhesion, spreading, growth, and differentiation. Here, we report for the first time the effects of four different emerging 2D materials on human adipose-derived mesenchymal stem cells (hADMSCs). Graphene oxide (GO), molybdenum sulfide (MoS2), tungsten sulfide (WS2), and boron nitride (BN) were selected as model two-dimensional materials and were coated on cell-culture substrates by a drop casting method. Acute toxicity was not observed with any of the four different 2D materials at a low concentration range (<5 mu g/ml). Interestingly, the 2D material-modified substrates exhibited a higher cell adhesion, spreading, and proliferation when compared with a non-treated (NT) substrate. Remarkably, in the case of differentiation, the MoS2-, WS2-, and BN-modified substrates exhibited a better performance in terms of guiding the adipogenesis of hADMSCs when compared with both NT and GO-modified substrates, based on the mRNA expression level (qPCR) and amount of lipid droplets (ORO staining). In contrast, the osteogenesis was found to be most efficiently induced by the GO-coated substrate (50 mu g/mL) among all 2D-material coated substrates. In summary, 2D materials could act as favorable sources for controlling the stem cell growth and differentiation, which might be highly advantageous in both biomedical research and therapy. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Effects of two-dimensional materials on human mesenchymal stem cell behaviors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.08.149 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.493, no.1, pp 578 - 584 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000413134200090 | - |
dc.identifier.scopusid | 2-s2.0-85028872464 | - |
dc.citation.endPage | 584 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 578 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 493 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Two-dimensional material | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Osteogenesis | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | TUNGSTEN DISULFIDE | - |
dc.subject.keywordPlus | GRAPHENE | - |
dc.subject.keywordPlus | MOS2 | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INTERCALATION | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordPlus | NANOSHEETS | - |
dc.subject.keywordPlus | CRYSTALS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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