화학물질 독성고속대량스크리닝 프로그램 ToxCastTM 분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정재성 | - |
dc.contributor.author | 임창원 | - |
dc.contributor.author | 정다운 | - |
dc.contributor.author | 최진희 | - |
dc.date.available | 2019-09-30T02:01:54Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 1226-9700 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36564 | - |
dc.description.abstract | As the number of new chemicals increases, traditional animal testinghas limitations in evaluating the toxicity of chemicals. In Europe and the United States, the use of non-animal alternative toxicity test methods for chemical regulation is encouraged and related research is actively carried out. In the United States, the ToxCast program is in progress using high-throughput screening (HTS) techniques. The program produced HTS in vitrotest results for 1200 assays and 9000 chemicals to develop chemical toxicity prediction models and set the priorities for toxicity assessment. In this review, we explored the outline of ToxCast, the types of assays used, and the progress of each phase. We also explored how to analyze the numerous toxicity data generated through the ToxCast program, including pre-processing, dose-response model fit, conclusion and categorization. Finally, implications for domestic utilization ofthe ToxCast database are derived. | - |
dc.format.extent | 7 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국환경분석학회 | - |
dc.title | 화학물질 독성고속대량스크리닝 프로그램 ToxCastTM 분석 | - |
dc.title.alternative | ToxCastTM Program for High Throughput Screening ofEnvironmentalChemical Toxicity, a Review | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 한국환경분석학회지, v.22, no.2, pp 77 - 83 | - |
dc.identifier.kciid | ART002483417 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 83 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 77 | - |
dc.citation.title | 한국환경분석학회지 | - |
dc.citation.volume | 22 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | ToxCast | - |
dc.subject.keywordAuthor | High Throughput Screening | - |
dc.subject.keywordAuthor | Chemical toxicity | - |
dc.subject.keywordAuthor | Data analysis | - |
dc.subject.keywordAuthor | Regulatory science | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.