Calcium-dependent prevention of neuronal apoptosis by lithium ion: Essential role of phosphoinositide 3-kinase and phospholipase C gamma
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyo Jung | - |
dc.contributor.author | Noh, Jai Sung | - |
dc.contributor.author | Bae, Yun Soo | - |
dc.contributor.author | Gwag, Byong Joo | - |
dc.date.available | 2019-09-30T02:10:07Z | - |
dc.date.issued | 2003-08 | - |
dc.identifier.issn | 0026-895X | - |
dc.identifier.issn | 1521-0111 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36715 | - |
dc.description.abstract | We examined the possibility that the neuroprotective effects of Li+ would depend upon the patterns of neuronal death, apoptosis versus necrosis, and whether Ca2+ as well as phosphoinositide 3-kinase (PI3-K) would mediate the neuroprotective effect of Li+. Cortical neurons treated with Li+ showed marked increase in [Ca2+](i) within 2 min. Addition of BAPTA-acetoxymethyl ester, a selective Ca2+ chelator, abrogated the antiapoptotic effect of Li+. PI3-K was activated rapidly within 1 min after exposure to Li+, which mediated Ca2+-dependent neuroprotective effects of Li+. Activated PI3-K seemed to increase [Ca2+](i) via the phospholipase Cgamma (PLCgamma) pathway. Antiapoptosis action of Li+ was prevented in the presence of U-73122, a selective phospholipase C inhibitor, and was not observed in PLCgamma1-null fibroblasts. In contrast to antiapoptosis action, administration of Li+ did not prevent neuronal cell necrosis by excitotoxicity or free radicals. Li+ selectively prevents apoptosis by increasing [Ca2+](i) through activation of PI3-K and PLCgamma pathways. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | - |
dc.title | Calcium-dependent prevention of neuronal apoptosis by lithium ion: Essential role of phosphoinositide 3-kinase and phospholipase C gamma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1124/mol.64.2.228 | - |
dc.identifier.bibliographicCitation | MOLECULAR PHARMACOLOGY, v.64, no.2, pp 228 - 234 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000184220900006 | - |
dc.identifier.scopusid | 2-s2.0-0042343738 | - |
dc.citation.endPage | 234 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 228 | - |
dc.citation.title | MOLECULAR PHARMACOLOGY | - |
dc.citation.volume | 64 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | GLYCOGEN-SYNTHASE KINASE-3-BETA | - |
dc.subject.keywordPlus | CULTURED CORTICAL-NEURONS | - |
dc.subject.keywordPlus | CEREBELLAR GRANULE CELLS | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | MOUSE CEREBRAL-CORTEX | - |
dc.subject.keywordPlus | D-ASPARTATE RECEPTOR | - |
dc.subject.keywordPlus | PROTEIN-KINASE-B | - |
dc.subject.keywordPlus | GLUCOSE DEPRIVATION | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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