Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, E.O. | - |
dc.contributor.author | Lee, H. | - |
dc.contributor.author | HwangBo, H. | - |
dc.contributor.author | Kwon, D.H. | - |
dc.contributor.author | Kim, M.Y. | - |
dc.contributor.author | Ji, S.Y. | - |
dc.contributor.author | Hong, S.H. | - |
dc.contributor.author | Kim, G.-Y. | - |
dc.contributor.author | Park, C. | - |
dc.contributor.author | Hwang, H.-J. | - |
dc.contributor.author | Moon, S.-K. | - |
dc.contributor.author | Yun, S.-J. | - |
dc.contributor.author | Kim, W.-J. | - |
dc.contributor.author | Choi, Y.H. | - |
dc.date.available | 2019-10-24T02:41:02Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.issn | 1099-1573 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36870 | - |
dc.description.abstract | The peel of Citrus unshiu Marcow. fruits (CU) has long been used as a traditional medicine that has therapeutic effects against pathogenic diseases, including asthma, vomiting, dyspepsia, blood circulation disorders, and various types of cancer. In this study, we investigated the effect of CU peel on metastatic melanoma, a highly aggressive skin cancer, in B16F10 melanoma cells, and in B16F10 cells inoculated-C57BL/6 mice. Our results show that ethanol extracts of CU (EECU) inhibited cell growth and increased the apoptotic cells in B16F10 cells. EECU also stimulated the induction of mitochondria-mediated intrinsic pathway, with reduced mitochondrial membrane potential and increased generation of intracellular reactive oxygen species. Furthermore, EECU suppressed the migration, invasion, and colony formation of B16F10 cells. In addition, the oral administration of EECU reduced serum lactate dehydrogenase activity without weight loss, hepatotoxicity, nor nephrotoxicity in B16F10 cell-inoculated mice. Moreover, EECU markedly suppressed lung hypertrophy, the number and expression of metastatic tumor nodules, and the expression of inflammatory tumor necrosis factor-alpha in lung tissue. In conclusion, our findings suggest that the inhibitory effect of EECU on the metastasis of melanoma indicates that it may be regarded as a potential therapeutic herbal drug for melanoma. © 2019 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley and Sons Ltd | - |
dc.title | Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ptr.6497 | - |
dc.identifier.bibliographicCitation | Phytotherapy Research, v.33, no.12, pp 3228 - 3241 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000520500000016 | - |
dc.identifier.scopusid | 2-s2.0-85071775864 | - |
dc.citation.endPage | 3241 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3228 | - |
dc.citation.title | Phytotherapy Research | - |
dc.citation.volume | 33 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | B16F10 cells | - |
dc.subject.keywordAuthor | Citrus unshiu (CU) | - |
dc.subject.keywordAuthor | melanoma | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | APOPTOSISP | - |
dc.subject.keywordPlus | HYTOCHEMICALS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MMP-2 | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | INACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.