Clinical Characteristics of Exacerbation-Prone Adult Asthmatics Identified by Cluster Analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi-Ae | - |
dc.contributor.author | Shin, Seung-Woo | - |
dc.contributor.author | Park, Jong-Sook | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Chang, Hun Soo | - |
dc.contributor.author | Bae, Da-Jeong | - |
dc.contributor.author | Cho, You Sook | - |
dc.contributor.author | Park, Hae-Sim | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Choi, Byoung Whui | - |
dc.contributor.author | Kim, Yong Hoon | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.date.available | 2019-03-08T07:38:00Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3710 | - |
dc.description.abstract | Purpose: Asthma is a heterogeneous disease characterized by various types of airway inflammation and obstruction. Therefore, it is classified into several subphenotypes, such as early-onset atopic, obese non-eosinophilic, benign, and eosinophilic asthma, using cluster analysis. A number of asthmatics frequently experience exacerbation over a long-term follow-up period, but the exacerbation-prone subphenotype has rarely been evaluated by cluster analysis. This prompted us to identify clusters reflecting asthma exacerbation. Methods: A uniform cluster analysis method was applied to 259 adult asthmatics who were regularly followed-up for over 1 year using 12 variables, selected on the basis of their contribution to asthma phenotypes. After clustering, clinical profiles and exacerbation rates during follow-up were compared among the clusters. Results: Four subphenotypes were identified: cluster 1 was comprised of patients with early-onset atopic asthma with preserved lung function, cluster 2 late-onset non-atopic asthma with impaired lung function, cluster 3 early-onset atopic asthma with severely impaired lung function, and cluster 4 late-onset non-atopic asthma with well-preserved lung function. The patients in clusters 2 and 3 were identified as exacerbation-prone asthmatics, showing a higher risk of asthma exacerbation. Conclusions: Two different phenotypes of exacerbation-prone asthma were identified among Korean asthmatics using cluster analysis; both were characterized by impaired lung function, but the age at asthma onset and atopic status were different between the two. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.title | Clinical Characteristics of Exacerbation-Prone Adult Asthmatics Identified by Cluster Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.4168/aair.2017.9.6.483 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.9, no.6, pp 483 - 490 | - |
dc.identifier.kciid | ART002280955 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000415392700004 | - |
dc.identifier.scopusid | 2-s2.0-85029526105 | - |
dc.citation.endPage | 490 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 483 | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | cluster analysis | - |
dc.subject.keywordAuthor | exacerbation | - |
dc.subject.keywordPlus | REFRACTORY ASTHMA | - |
dc.subject.keywordPlus | AIRWAY-OBSTRUCTION | - |
dc.subject.keywordPlus | PHENOTYPES | - |
dc.subject.keywordPlus | OMALIZUMAB | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | ONSET | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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